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rdf:type |
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lifeskim:mentions |
umls-concept:C0019187,
umls-concept:C0023884,
umls-concept:C0030705,
umls-concept:C0042971,
umls-concept:C0205216,
umls-concept:C0205217,
umls-concept:C0231174,
umls-concept:C0441655,
umls-concept:C1413036,
umls-concept:C1527148,
umls-concept:C1880177,
umls-concept:C2699787
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pubmed:issue |
1 Suppl
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pubmed:dateCreated |
2007-3-2
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pubmed:abstractText |
Severe alcoholic hepatitis (SAH) in addition to alcoholic hepatitis (AH) is a life-threatening complication of alcohol abuse, and its pathogenesis remains unclear. The deficiency of ADAMTS13 results in an increase of the plasma unusually large von Willebrand factor multimer (UL-VWFM) and finally causes microcirculatory disturbance and multiorgan failure. We investigated the relationship of ADAMTS13 and von Willebrand factor antigen (VWF:Ag) with the clinical features of AH and SAH.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1530-0277
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pubmed:author |
pubmed-author:FujimotoMasaoM,
pubmed-author:FujimuraYoshihiroY,
pubmed-author:FukuiHiroshiH,
pubmed-author:IshikawaMasatoshiM,
pubmed-author:IshizashiHiromichiH,
pubmed-author:KatoSeijiS,
pubmed-author:KojimaHideyukiH,
pubmed-author:MatsumotoMasanoriM,
pubmed-author:MatsuyamaTomomiT,
pubmed-author:MoriokaChieC,
pubmed-author:TakimuraChikaraC,
pubmed-author:UemuraMasahitoM,
pubmed-author:YoshijiHitoshiH
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S27-35
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17331163-ADAM Proteins,
pubmed-meshheading:17331163-Adult,
pubmed-meshheading:17331163-Aged,
pubmed-meshheading:17331163-Antigens,
pubmed-meshheading:17331163-Female,
pubmed-meshheading:17331163-Hepatitis, Alcoholic,
pubmed-meshheading:17331163-Humans,
pubmed-meshheading:17331163-Liver Cirrhosis, Alcoholic,
pubmed-meshheading:17331163-Liver Function Tests,
pubmed-meshheading:17331163-Male,
pubmed-meshheading:17331163-Middle Aged,
pubmed-meshheading:17331163-Multiple Organ Failure,
pubmed-meshheading:17331163-Predictive Value of Tests,
pubmed-meshheading:17331163-Prognosis,
pubmed-meshheading:17331163-Risk Factors,
pubmed-meshheading:17331163-von Willebrand Factor
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pubmed:year |
2007
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pubmed:articleTitle |
Increased von Willebrand factor over decreased ADAMTS13 activity may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis.
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pubmed:affiliation |
Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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