Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-3-2
pubmed:abstractText
To investigate the viral features of long-term nonprogressive HIV-1 infection and the selection of viral genomes, we studied serial complete HIV-1 sequences obtained from a mother-child pair, both long-term nonprogressors. Analysis of four genomic sequences demonstrated that all viral genes were intact, lacking major deletions or premature stop codons to easily explain the slow disease progression. These data suggest that viral attenuation, if present, was caused by subtle sequence variations or virus-host interactions. Serial sequences from an HIV-1-infected mother-child pair afforded us the opportunity to examine the immune selection of HIV-1 sequences years after transmission between individuals. We demonstrated that the daughter's strains were most likely subjected to immunoselection or immunoediting according to the presence of novel MHC class I alleles that differed between mother and daughter. An analysis of nef-specific cytotoxic T-lymphocyte responses in the child, whose HIV-1 nef sequence differed from the maternal nef, supported this interpretation. This study highlights the potential of full genome analysis in the investigation of pathogenesis and immune selection during HIV-1 evolution.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-10572315, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-10716496, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-10756051, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-11160723, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-11181642, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-11375420, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-11460164, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-11679152, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-12029127, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-12351948, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-12584330, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-12750404, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-14770175, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-15795524, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-16522810, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-7828077, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-8618852, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-8985398, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-9188549, http://linkedlifedata.com/resource/pubmed/commentcorrection/17331038-9923748
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0889-2229
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
309-15
pubmed:dateRevised
2011-5-4
pubmed:meshHeading
pubmed-meshheading:17331038-Adult, pubmed-meshheading:17331038-Child, Preschool, pubmed-meshheading:17331038-Disease Progression, pubmed-meshheading:17331038-Evolution, Molecular, pubmed-meshheading:17331038-Female, pubmed-meshheading:17331038-Gene Products, nef, pubmed-meshheading:17331038-Genes, MHC Class I, pubmed-meshheading:17331038-HIV Infections, pubmed-meshheading:17331038-HIV Long-Term Survivors, pubmed-meshheading:17331038-HIV-1, pubmed-meshheading:17331038-Humans, pubmed-meshheading:17331038-Infant, Newborn, pubmed-meshheading:17331038-Infectious Disease Transmission, Vertical, pubmed-meshheading:17331038-Molecular Sequence Data, pubmed-meshheading:17331038-Pregnancy, pubmed-meshheading:17331038-Retroviridae Proteins, pubmed-meshheading:17331038-Selection, Genetic, pubmed-meshheading:17331038-nef Gene Products, Human Immunodeficiency Virus
pubmed:year
2007
pubmed:articleTitle
Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors.
pubmed:affiliation
Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural