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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-3-21
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pubmed:abstractText |
Interleukin-4 (IL-4) is an antiinflammatory cytokine that inhibits the onset and severity of proteoglycan-induced arthritis (PGIA). To distinguish the role of IL-4 in the innate immune response versus the adaptive immune response, we generated mice with a specific deletion of the IL-4 receptor alpha-chain (IL-4Ralpha) in macrophages and neutrophils.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
861-70
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17330244-Animals,
pubmed-meshheading:17330244-Arthritis, Rheumatoid,
pubmed-meshheading:17330244-Female,
pubmed-meshheading:17330244-Gene Expression Regulation,
pubmed-meshheading:17330244-Immunity, Innate,
pubmed-meshheading:17330244-Interleukin-1beta,
pubmed-meshheading:17330244-Interleukin-4,
pubmed-meshheading:17330244-Interleukin-6,
pubmed-meshheading:17330244-Mice,
pubmed-meshheading:17330244-Mice, Inbred BALB C,
pubmed-meshheading:17330244-Mice, Inbred C3H,
pubmed-meshheading:17330244-Mice, Knockout,
pubmed-meshheading:17330244-Proteoglycans,
pubmed-meshheading:17330244-Receptors, Cell Surface,
pubmed-meshheading:17330244-Severity of Illness Index
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pubmed:year |
2007
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pubmed:articleTitle |
Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response.
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pubmed:affiliation |
Rush University Medical Center, Chicago, Illinois 60612, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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