Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2007-5-14
pubmed:abstractText
Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory stimuli, including bacterial and viral infections. SAA was recently found to function as an opsonin for gram-negative bacteria. We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-10504381, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-10535997, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-11121061, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-11880053, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-12056504, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-12356718, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-12438626, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-12913001, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-12951366, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-14722300, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-15358117, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-15561721, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-15576377, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-15701697, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-15705572, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-15827192, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-15939869, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-15947137, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-15951748, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-16120612, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-16254332, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-16380814, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-16380821, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-16474148, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-16603507, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-16651021, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-16735604, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-16840729, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-17050612, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-8817153, http://linkedlifedata.com/resource/pubmed/commentcorrection/17329325-9794763
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6128-33
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Human serum amyloid A protein inhibits hepatitis C virus entry into cells.
pubmed:affiliation
Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural