| pubmed-article:17329213 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17329213 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:17329213 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:17329213 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:17329213 | lifeskim:mentions | umls-concept:C0019652 | lld:lifeskim |
| pubmed-article:17329213 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:17329213 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:17329213 | lifeskim:mentions | umls-concept:C0033666 | lld:lifeskim |
| pubmed-article:17329213 | lifeskim:mentions | umls-concept:C0234621 | lld:lifeskim |
| pubmed-article:17329213 | lifeskim:mentions | umls-concept:C0678558 | lld:lifeskim |
| pubmed-article:17329213 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17329213 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:17329213 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17329213 | pubmed:dateCreated | 2007-3-1 | lld:pubmed |
| pubmed-article:17329213 | pubmed:abstractText | The action of visual experience on visual cortical circuits is maximal during a critical period of postnatal development. The long-term effects of this experience are likely mediated by signaling cascades regulating experience-dependent gene transcription. Developmental modifications of these pathways could explain the difference in plasticity between the young and adult cortex. We studied the pathways linking experience-dependent activation of ERK to CREB-mediated gene expression in vivo. In juvenile mice, visual stimulation that activates CREB-mediated gene transcription also induced ERK-dependent MSK and histone H3 phosphorylation and H3-H4 acetylation, an epigenetic mechanism of gene transcription activation. In adult animals, ERK and MSK were still inducible; however, visual stimulation induced weak CREB-mediated gene expression and H3-H4 posttranslational modifications. Stimulation of histone acetylation in adult animals by means of trichostatin promoted ocular dominance plasticity. Thus, differing, experience-dependent activations of signaling molecules might be at the basis of the differences in experience-dependent plasticity between juvenile and adult cortex. | lld:pubmed |
| pubmed-article:17329213 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17329213 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17329213 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17329213 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17329213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17329213 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17329213 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17329213 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:17329213 | pubmed:author | pubmed-author:CostaMarioM | lld:pubmed |
| pubmed-article:17329213 | pubmed:author | pubmed-author:MaffeiLambert... | lld:pubmed |
| pubmed-article:17329213 | pubmed:author | pubmed-author:PizzorussoTom... | lld:pubmed |
| pubmed-article:17329213 | pubmed:author | pubmed-author:CanceddaLaura... | lld:pubmed |
| pubmed-article:17329213 | pubmed:author | pubmed-author:PutignanoElen... | lld:pubmed |
| pubmed-article:17329213 | pubmed:author | pubmed-author:LonettiGiusep... | lld:pubmed |
| pubmed-article:17329213 | pubmed:author | pubmed-author:RattoGianmich... | lld:pubmed |
| pubmed-article:17329213 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17329213 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17329213 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:17329213 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17329213 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17329213 | pubmed:pagination | 747-59 | lld:pubmed |
| pubmed-article:17329213 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17329213 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17329213 | pubmed:articleTitle | Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity. | lld:pubmed |
| pubmed-article:17329213 | pubmed:affiliation | Scuola Normale Superiore, Neurobiology Laboratory, Area Ricerca CNR, via Moruzzi, 1 Pisa 56125, Italy. | lld:pubmed |
| pubmed-article:17329213 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17329213 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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