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rdf:type |
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lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0013081,
umls-concept:C0019652,
umls-concept:C0022655,
umls-concept:C0033666,
umls-concept:C0234621,
umls-concept:C0458003,
umls-concept:C0678558,
umls-concept:C0678723,
umls-concept:C0851285
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pubmed:issue |
5
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pubmed:dateCreated |
2007-3-1
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pubmed:abstractText |
The action of visual experience on visual cortical circuits is maximal during a critical period of postnatal development. The long-term effects of this experience are likely mediated by signaling cascades regulating experience-dependent gene transcription. Developmental modifications of these pathways could explain the difference in plasticity between the young and adult cortex. We studied the pathways linking experience-dependent activation of ERK to CREB-mediated gene expression in vivo. In juvenile mice, visual stimulation that activates CREB-mediated gene transcription also induced ERK-dependent MSK and histone H3 phosphorylation and H3-H4 acetylation, an epigenetic mechanism of gene transcription activation. In adult animals, ERK and MSK were still inducible; however, visual stimulation induced weak CREB-mediated gene expression and H3-H4 posttranslational modifications. Stimulation of histone acetylation in adult animals by means of trichostatin promoted ocular dominance plasticity. Thus, differing, experience-dependent activations of signaling molecules might be at the basis of the differences in experience-dependent plasticity between juvenile and adult cortex.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Creb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases, 90-kDa,
http://linkedlifedata.com/resource/pubmed/chemical/mitogen and stress-activated...,
http://linkedlifedata.com/resource/pubmed/chemical/trichostatin A
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
747-59
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17329213-Acetylation,
pubmed-meshheading:17329213-Age Factors,
pubmed-meshheading:17329213-Animals,
pubmed-meshheading:17329213-Critical Period (Psychology),
pubmed-meshheading:17329213-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:17329213-Dominance, Cerebral,
pubmed-meshheading:17329213-Down-Regulation,
pubmed-meshheading:17329213-Epigenesis, Genetic,
pubmed-meshheading:17329213-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:17329213-Gene Expression Regulation,
pubmed-meshheading:17329213-Histones,
pubmed-meshheading:17329213-Hydroxamic Acids,
pubmed-meshheading:17329213-MAP Kinase Signaling System,
pubmed-meshheading:17329213-Mice,
pubmed-meshheading:17329213-Mice, Inbred C57BL,
pubmed-meshheading:17329213-Neuronal Plasticity,
pubmed-meshheading:17329213-Phosphorylation,
pubmed-meshheading:17329213-Photic Stimulation,
pubmed-meshheading:17329213-Protein Processing, Post-Translational,
pubmed-meshheading:17329213-Protein Synthesis Inhibitors,
pubmed-meshheading:17329213-Ribosomal Protein S6 Kinases, 90-kDa,
pubmed-meshheading:17329213-Visual Cortex
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pubmed:year |
2007
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pubmed:articleTitle |
Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity.
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pubmed:affiliation |
Scuola Normale Superiore, Neurobiology Laboratory, Area Ricerca CNR, via Moruzzi, 1 Pisa 56125, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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