Linked Life Data

17328723

Source:http://linkedlifedata.com/resource/pubmed/id/17328723

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-3-1
pubmed:abstractText
Tuberculosis continues to be the main cause of death from a single infectious agent in developing countries. The causative agent, Mycobacterium tuberculosis, is thought to have diverged from its common ancestor as recently as 15,000 years ago. Subsequently, various genetic elements have evolved over time at different rates and can be used to elucidate patterns of infection. When individual elements are studied within genetic families, very low rates of variation are observed for almost every marker. For example, when all M. tuberculosis genetic families are considered, the number of alleles observed at each mycobacterial interspersed repetitive unit (MIRU) locus usually drops when viewed within a single genetic family, indicating that the rate of repeat variation may be low, as each member of that family is a descendant of a single common ancestor. Also, the low level of silent nucleotide variation observed indicates that M. tuberculosis is, in evolutionary terms, very young. Mapping the variation of the different markers used in molecular epidemiology within a genetic framework enables the relative rates of variation of these markers to be determined and, together with a complete chronology, allows the identification of more informative panels of markers tailored to individual genetic families.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1198-743X
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
120-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Molecular evolution of Mycobacterium tuberculosis.
pubmed:affiliation
Applied and Functional Genomics, Centre for Infections, Health Protection Agency, London, UK. catherine.arnold@hpa.org.uk
pubmed:publicationType
Journal Article, Review