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rdf:type |
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lifeskim:mentions |
umls-concept:C0005516,
umls-concept:C0021743,
umls-concept:C0024432,
umls-concept:C0026473,
umls-concept:C0030705,
umls-concept:C0036421,
umls-concept:C0142251,
umls-concept:C0175630,
umls-concept:C0205217,
umls-concept:C0205263,
umls-concept:C0243192,
umls-concept:C0670896,
umls-concept:C1420266
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pubmed:issue |
3
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pubmed:dateCreated |
2007-3-21
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pubmed:abstractText |
Microarray analyses of peripheral blood leukocytes have shown that patients with systemic lupus erythematosus express increased levels of type I interferon (IFN)-regulated genes. In this study we examined gene expression by peripheral blood mononuclear cells (PBMCs) from patients with systemic sclerosis (SSc) to better understand the dysregulation of the immune system in this disease.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/erythrocyte receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1010-20
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:17328080-Adolescent,
pubmed-meshheading:17328080-Adult,
pubmed-meshheading:17328080-Aged,
pubmed-meshheading:17328080-Antigens, CD14,
pubmed-meshheading:17328080-Biological Markers,
pubmed-meshheading:17328080-Case-Control Studies,
pubmed-meshheading:17328080-Cells, Cultured,
pubmed-meshheading:17328080-Female,
pubmed-meshheading:17328080-Gene Expression Regulation,
pubmed-meshheading:17328080-Humans,
pubmed-meshheading:17328080-Interferon Type I,
pubmed-meshheading:17328080-Male,
pubmed-meshheading:17328080-Membrane Glycoproteins,
pubmed-meshheading:17328080-Microarray Analysis,
pubmed-meshheading:17328080-Middle Aged,
pubmed-meshheading:17328080-Monocytes,
pubmed-meshheading:17328080-RNA, Messenger,
pubmed-meshheading:17328080-Receptors, Immunologic,
pubmed-meshheading:17328080-Scleroderma, Systemic,
pubmed-meshheading:17328080-Toll-Like Receptors
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pubmed:year |
2007
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pubmed:articleTitle |
A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists.
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pubmed:affiliation |
Boston University Medical Center, Boston, Massachusetts 02118, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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