Source:http://linkedlifedata.com/resource/pubmed/id/17327448
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2007-2-28
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pubmed:abstractText |
Sources of plasma glucose and glucose turnover were investigated in 8-week-old (pre-diabetic) and 13-week-old (diabetic) Zucker (fa/fa) rats after a 24-h fast. Intraperitoneal (2)H(2)O was administered and [3,4-(13)C(2)]glucose and [U-(13)C(3)]propionate were infused into conscious active rats. (13)C nuclear magnetic resonance analysis of monoacetone glucose derived from blood glucose indicated that glucose production was increased significantly in 8- and 13-week-old fa/fa rats compared with age-matched Zucker (+/+) rats, and hepatic glycogen was dramatically higher among fa/fa animals regardless of age. Glycogenolysis, essentially 0 in +/+ rats after a 24-h fast, was significant in fa/fa rats (11 +/- 6 and 17 +/- 7% of glucose production in 8- and 13-week-old rats, respectively), even after a 24-h fast. Tricarboxylic acid (TCA) cycle flux and efflux of carbon skeletons from the cycle (cataplerosis) were both significantly higher in fa/fa rats compared with controls, but net gluconeogenesis from the TCA cycle was not higher because products leaving the cycle were returned to the cycle via a pyruvate cycling pathway. Thus, pyruvate cycling flux increased in proportion to TCA cycle flux, leaving net gluconeogenesis unchanged in fa/fa animals compared with control animals. The distribution of (2)H in skeletal muscle glycogen suggested that at least a fraction of glucose molecules entering glycogen pass through phosphomannose isomerase.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0012-1797
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
777-85
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17327448-Aging,
pubmed-meshheading:17327448-Animals,
pubmed-meshheading:17327448-Blood Glucose,
pubmed-meshheading:17327448-Citric Acid Cycle,
pubmed-meshheading:17327448-Diabetes Mellitus,
pubmed-meshheading:17327448-Glucose,
pubmed-meshheading:17327448-Glycogenolysis,
pubmed-meshheading:17327448-Hyperglycemia,
pubmed-meshheading:17327448-Liver,
pubmed-meshheading:17327448-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17327448-Male,
pubmed-meshheading:17327448-Muscle, Skeletal,
pubmed-meshheading:17327448-Prediabetic State,
pubmed-meshheading:17327448-Rats,
pubmed-meshheading:17327448-Rats, Zucker
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pubmed:year |
2007
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pubmed:articleTitle |
Role of excess glycogenolysis in fasting hyperglycemia among pre-diabetic and diabetic Zucker (fa/fa) rats.
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pubmed:affiliation |
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8568, USA. eunsook.jin@utsouthwestern.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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