Source:http://linkedlifedata.com/resource/pubmed/id/17327427
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2007-2-28
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pubmed:abstractText |
Regulatory T-cells (Tregs) play a critical role in maintaining dominant peripheral tolerance. Previous characterizations of Tregs in type 1 diabetes have used antibodies against CD4 and alpha-chain of the interleukin-2 receptor complex (CD25). This report extends those investigations by the addition of a more lineage-specific marker for Tregs, transcription factor forkhead box P3 (FOXP3), in subjects with type 1 diabetes, their first-degree relatives, and healthy control subjects. With inclusion of this marker, two predominant populations of CD4(+)CD25(+) T-cells were identified: CD4(+)CD25(+)FOXP3(+) as well as CD4(+)FOXP3(-) T-cells expressing low levels of CD25 (CD4(+)CD25(LOW)FOXP3(-)). In all study groups, the frequency of CD4(+)CD25(+)FOXP3(+) cells was age independent, whereas CD4(+)CD25(LOW)FOXP3(-) cell frequencies strongly associated with age. In terms of additional markers for delineating cells of Treg lineage, FOXP3(+) cells were CD127(-) to CD127(LOW) whereas CD25(+) cells were less restricted in their expression of this marker, with CD127 expressed across a continuum of levels. Importantly, no differences were observed in the frequency of CD4(+)CD25(+)FOXP3(+) T-cells in individuals with or at varying degrees of risk for type 1 diabetes. These investigations suggest that altered peripheral blood frequencies of Tregs, as defined by the expression of FOXP3, are not specifically associated with type 1 diabetes and continue to highlight age as an important variable in analysis of immune regulation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/FOXP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0012-1797
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pubmed:author |
pubmed-author:AtkinsonMarkM,
pubmed-author:BruskoToddT,
pubmed-author:Clare-SalzlerMichaelM,
pubmed-author:GottliebPeterP,
pubmed-author:HallerMichaelM,
pubmed-author:McGrailKieranK,
pubmed-author:RockellJenniferJ,
pubmed-author:SchatzDesmondD,
pubmed-author:SchatzRichardR,
pubmed-author:VienerHilla LeeHL,
pubmed-author:WasserfallCliveC
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
604-12
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17327427-Adolescent,
pubmed-meshheading:17327427-Adult,
pubmed-meshheading:17327427-Aging,
pubmed-meshheading:17327427-Antigens, CD45,
pubmed-meshheading:17327427-Biological Markers,
pubmed-meshheading:17327427-Child,
pubmed-meshheading:17327427-Diabetes Mellitus, Type 1,
pubmed-meshheading:17327427-Female,
pubmed-meshheading:17327427-Forkhead Transcription Factors,
pubmed-meshheading:17327427-Gene Expression Regulation,
pubmed-meshheading:17327427-Humans,
pubmed-meshheading:17327427-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:17327427-Male,
pubmed-meshheading:17327427-Middle Aged,
pubmed-meshheading:17327427-Protein Tyrosine Phosphatase, Non-Receptor Type 1,
pubmed-meshheading:17327427-T-Lymphocytes, Regulatory,
pubmed-meshheading:17327427-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes.
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pubmed:affiliation |
Department of Pathology, College of Medicine, University of Florida, 1600 SW Archer Rd., Gainesville, FL 32610-0275, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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