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rdf:type |
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lifeskim:mentions |
umls-concept:C0015087,
umls-concept:C0024121,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0026882,
umls-concept:C0027651,
umls-concept:C0178784,
umls-concept:C0205214,
umls-concept:C0332290,
umls-concept:C0441712,
umls-concept:C1326912,
umls-concept:C2698297
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pubmed:issue |
1
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pubmed:dateCreated |
2007-2-27
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pubmed:abstractText |
Ethylene oxide is a multisite carcinogen in rodents and classified as a human carcinogen by the National Toxicology Program. In 2-year mouse studies, ethylene oxide (EO) induced lung, Harderian gland (HG), and uterine neoplasms. We evaluated representative EO-induced and equivalent spontaneous neoplasms for K-ras mutations in codons 12, 13, and 61. K-ras mutations were identified in 100% (23/23) of the EO-induced lung neoplasms and 25% (27/108) of the spontaneous lung neoplasms. Codon 12 G to T transversions were common in EO-induced lung neoplasms (21/23) but infrequent in spontaneous lung neoplasms (1/108). K-ras mutations were found in 86% (18/21) of the EO-induced HG neoplasms and 7% (2/27) of the spontaneous HG neoplasms. Codon 13 G to C and codon 12 G to T transversions were predominant in the EO-induced HG neoplasms but absent in spontaneous HG neoplasms (0/27). K-ras mutations occurred in 83% (5/6) of the EO-induced uterine carcinomas and all were codon 13 C to T transitions. These data show a strong predilection for development of K-ras mutations in EO-induced lung, Harderian gland, and uterine neoplasms. This suggests that EO specifically targets the K-ras gene in multiple tissue types and that this event is a critical component of EO-induced tumorigenesis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-10223196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-10469625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-10636004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-10686305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-10964097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-11179836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-11377244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-11560247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-12562636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-1371589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-15123787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-15809715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-1643630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-1643667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-1719390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-1995195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-2020295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-2244961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-2302758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-5325210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-7506366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-7591956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-7600534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-7614698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-7869568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-7955123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-7957119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-8280635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-8504471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-8560484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-9111215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-9268040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-9514049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325976-9818781
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0192-6233
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-5
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pubmed:dateRevised |
2011-9-15
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pubmed:meshHeading |
pubmed-meshheading:17325976-Adenocarcinoma,
pubmed-meshheading:17325976-Adenoma,
pubmed-meshheading:17325976-Animals,
pubmed-meshheading:17325976-Carcinogens,
pubmed-meshheading:17325976-DNA, Neoplasm,
pubmed-meshheading:17325976-Disinfectants,
pubmed-meshheading:17325976-Dose-Response Relationship, Drug,
pubmed-meshheading:17325976-Ethylene Oxide,
pubmed-meshheading:17325976-Female,
pubmed-meshheading:17325976-Genes, ras,
pubmed-meshheading:17325976-Harderian Gland,
pubmed-meshheading:17325976-Inhalation Exposure,
pubmed-meshheading:17325976-Lung Neoplasms,
pubmed-meshheading:17325976-Male,
pubmed-meshheading:17325976-Mice,
pubmed-meshheading:17325976-Mice, Inbred Strains,
pubmed-meshheading:17325976-Mutation,
pubmed-meshheading:17325976-Sebaceous Gland Neoplasms,
pubmed-meshheading:17325976-Uterine Neoplasms
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pubmed:year |
2007
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pubmed:articleTitle |
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
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pubmed:affiliation |
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. hong5@niehs.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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