Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1992-2-25
|
pubmed:abstractText |
The synthesis of 8-hydroxy and 8-methoxy analogues of some substituted 5-aminoimidazoacridinones (4) is described. The synthesis was carried out by a three-step sequence from the corresponding 1-chloro-4-nitro-9(10H)-acridinone precursors (1). The annulation of the imidazolo ring onto the aminoacridinone chromophore was accomplished by heating the required aminoacridinone (3) with formic acid or, in the case of 1-methyl derivatives, with N,N-dimethylacetamide. Potent cytotoxic activity against L1210 leukemia, as well as antitumor activity against P388 leukemia in mice, was demonstrated for the 8-hydroxy analogues. The corresponding 8-methoxy derivatives were not cytotoxic. However, in some cases, they showed significant in vivo antileukemic activity.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
24
|
pubmed:volume |
35
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
378-82
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1732555-Aminoacridines,
pubmed-meshheading:1732555-Animals,
pubmed-meshheading:1732555-Antineoplastic Agents,
pubmed-meshheading:1732555-Imidazoles,
pubmed-meshheading:1732555-Leukemia, Experimental,
pubmed-meshheading:1732555-Leukemia L1210,
pubmed-meshheading:1732555-Leukemia P388,
pubmed-meshheading:1732555-Male,
pubmed-meshheading:1732555-Mice,
pubmed-meshheading:1732555-Structure-Activity Relationship,
pubmed-meshheading:1732555-Tumor Cells, Cultured
|
pubmed:year |
1992
|
pubmed:articleTitle |
Chromophore-modified antineoplastic imidazoacridinones. Synthesis and activity against murine leukemias.
|
pubmed:affiliation |
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|