Linked Life Data

17325218

Source:http://linkedlifedata.com/resource/pubmed/id/17325218

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-4-23
pubmed:abstractText
Resistance to fusidic acid in Staphylococcus aureus often results from acquisition of the fusB determinant or from mutations in the gene (fusA) that encodes the drug target (elongation factor G). We now report further studies on the genetic basis of resistance to this antibiotic in the staphylococci. Two staphylococcal genes that encode proteins exhibiting ca. 45% identity with FusB conferred resistance to fusidic acid in S. aureus. One of these genes (designated fusC) was subsequently detected in all fusidic acid-resistant clinical strains of S. aureus tested that did not carry fusB or mutations in fusA, and in strains of S. intermedius. The other gene (designated fusD) is carried by S. saprophyticus, explaining the inherent resistance of this species to fusidic acid. Fusidic acid-resistant strains of S. lugdunensis harbored fusB. Thus, resistance to fusidic acid in clinical isolates of S. aureus and other staphylococcal species frequently results from expression of FusB-type proteins.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-10348788, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-11705967, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-12477322, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-14657089, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-14738778, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-15213324, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-15328136, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-1551392, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-16135568, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-16390458, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-4604092, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-4900137, http://linkedlifedata.com/resource/pubmed/commentcorrection/17325218-6411618
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1737-40
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Genetic basis of resistance to fusidic acid in staphylococci.
pubmed:affiliation
Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't