Linked Life Data

17324513

Source:http://linkedlifedata.com/resource/pubmed/id/17324513

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-3-12
pubmed:abstractText
The protease thrombin is not only known as a major component in the blood coagulation cascade but is also involved in proinflammatory processes in the central nervous system (CNS). Here we used an in vitro model, to investigate the effect of thrombin and protease-activated receptor-1 (PAR-1) on proliferation and microgliosis after traumatic injury. A 5-day exposure to thrombin after cutting the Schaffer collaterals induced a proliferation and microgliosis in the dentate gyrus of organotypic slice cultures. This effect is at least partially mediated by PAR-1 since the selective peptide agonist TRag shows similar effects. Thus, thrombin effects after injury might involve microglial proliferation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
415
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-21
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Protease-activated receptor-1 induces generation of new microglia in the dentate gyrus of traumatised hippocampal slice cultures.
pubmed:affiliation
Leibniz Institut für Neurobiologie, Brennecke Str. 6, 39118 Magdeburg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't