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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-2-27
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pubmed:abstractText |
Because of a developing resistance to chemotherapy agents, multiple myeloma (MM) has been an incurable disease until now. As a means to overcome MM tumor cell resistance and/or sensitize tumor cells to chemotherapeutic treatments currently used, we examined the role of human apurinic/apyrimidinic endonuclease 1 (APE1) in resistance and prognosis in patients with MM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1557-9190
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
296-304
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pubmed:meshHeading |
pubmed-meshheading:17324338-Antigens, CD38,
pubmed-meshheading:17324338-Antineoplastic Agents,
pubmed-meshheading:17324338-Apoptosis,
pubmed-meshheading:17324338-Blotting, Western,
pubmed-meshheading:17324338-Cell Line, Tumor,
pubmed-meshheading:17324338-Cell Proliferation,
pubmed-meshheading:17324338-DNA-(Apurinic or Apyrimidinic Site) Lyase,
pubmed-meshheading:17324338-Dose-Response Relationship, Drug,
pubmed-meshheading:17324338-Drug Resistance, Neoplasm,
pubmed-meshheading:17324338-Feasibility Studies,
pubmed-meshheading:17324338-Female,
pubmed-meshheading:17324338-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17324338-Genetic Vectors,
pubmed-meshheading:17324338-Humans,
pubmed-meshheading:17324338-Immunohistochemistry,
pubmed-meshheading:17324338-Male,
pubmed-meshheading:17324338-Melphalan,
pubmed-meshheading:17324338-Microscopy, Confocal,
pubmed-meshheading:17324338-Middle Aged,
pubmed-meshheading:17324338-Multiple Myeloma,
pubmed-meshheading:17324338-Prognosis,
pubmed-meshheading:17324338-RNA, Small Interfering,
pubmed-meshheading:17324338-Sensitivity and Specificity,
pubmed-meshheading:17324338-Time Factors,
pubmed-meshheading:17324338-Tumor Cells, Cultured
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pubmed:year |
2007
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pubmed:articleTitle |
Experimental study enhancing the chemosensitivity of multiple myeloma to melphalan by using a tissue-specific APE1-silencing RNA expression vector.
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pubmed:affiliation |
Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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