Source:http://linkedlifedata.com/resource/pubmed/id/17323995
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2007-4-27
|
| pubmed:abstractText |
Five new limonoids, granaxylocarpins A-E (1-5), were isolated from the seeds of the Chinese marine mangrove Xylocarpus granatum. Granaxylocarpins A (1) and B (2) are mexicanolide-type limonoids with a 9,10-seco skeleton, and granaxylocarpin C (3) possesses an 8alpha,30alpha-epoxy ring and a rare 1,29-oxygen bridge. The structures of these limonoids were characterized on the basis of extensive spectroscopic methods and single-crystal X-ray diffraction analysis performed on 4. The structure of xyloccensin U (4a) was revised as 4b by comparison with granaxylocarpin D (4). The cytotoxicity of these isolates was evaluated against the P-388 and A-549 tumor cell lines.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0163-3864
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
70
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
682-5
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| pubmed:meshHeading |
pubmed-meshheading:17323995-Animals,
pubmed-meshheading:17323995-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:17323995-Crystallography, X-Ray,
pubmed-meshheading:17323995-Drug Screening Assays, Antitumor,
pubmed-meshheading:17323995-Drugs, Chinese Herbal,
pubmed-meshheading:17323995-Humans,
pubmed-meshheading:17323995-Leukemia P388,
pubmed-meshheading:17323995-Limonins,
pubmed-meshheading:17323995-Meliaceae,
pubmed-meshheading:17323995-Mice,
pubmed-meshheading:17323995-Molecular Structure,
pubmed-meshheading:17323995-Plants, Medicinal,
pubmed-meshheading:17323995-Seeds
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Limonoids from the seeds of the marine mangrove Xylocarpus granatum.
|
| pubmed:affiliation |
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|