| pubmed-article:17322376 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17322376 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17322376 | lifeskim:mentions | umls-concept:C0032043 | lld:lifeskim |
| pubmed-article:17322376 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:17322376 | lifeskim:mentions | umls-concept:C0032914 | lld:lifeskim |
| pubmed-article:17322376 | lifeskim:mentions | umls-concept:C1135936 | lld:lifeskim |
| pubmed-article:17322376 | lifeskim:mentions | umls-concept:C0017887 | lld:lifeskim |
| pubmed-article:17322376 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:17322376 | lifeskim:mentions | umls-concept:C0302350 | lld:lifeskim |
| pubmed-article:17322376 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:17322376 | pubmed:dateCreated | 2007-2-26 | lld:pubmed |
| pubmed-article:17322376 | pubmed:abstractText | Damage of the placenta resulting from ischemia-reperfusion is important to the pathophysiology of preeclampsia. Here we investigated whether low concentrations of glyceryl trinitrate (GTN), a nitric oxide mimetic with anti-apoptotic properties, inhibit hypoxia/reoxygenation-induced apoptosis in the syncytiotrophoblast of chorionic villous explants from human placentas. Compared with villi analyzed immediately after delivery or maintained under normoxic conditions, villi exposed to a 6-hour cycle of hypoxia/reoxygenation exhibited greater numbers of syncytiotrophoblasts with terminal dUTP nick-end labeling (TUNEL)-positive nuclei in the syncytiotrophoblast. This increased number of TUNEL-positive nuclei was paralleled by higher levels of 4-hydroxynonenal (marker of lipid peroxidation), nitrotyrosine residues, and active caspase-3 and polyADP-ribose polymerase expression. Morphological analysis of explants exposed to hypoxia/reoxygenation revealed apoptotic and aponecrotic features similar to those of chorionic villi from preeclamptic pregnancies. Treatment with GTN during the hy-poxia/reoxygenation cycle blocked the increases in the number of TUNEL-positive nuclei and in the levels of 4-hydroxynonenal, nitrotyrosine, and active caspase-3. Incubation with GTN also attenuated the hypoxia/reoxygenation-induced polyADP-ribose polymerase expression and the apoptotic and aponecrotic morphological alterations. These results suggest that small concentrations of nitric oxide protect chorionic villi from hypoxia/reoxygenation-induced damage and provide a rationale for the use of low doses of nitric oxide mimetics in the treatment and/or prevention of preeclampsia. | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17322376 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17322376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17322376 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17322376 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17322376 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:17322376 | pubmed:author | pubmed-author:GrahamCharles... | lld:pubmed |
| pubmed-article:17322376 | pubmed:author | pubmed-author:SmithGraeme... | lld:pubmed |
| pubmed-article:17322376 | pubmed:author | pubmed-author:BelkacemiLoui... | lld:pubmed |
| pubmed-article:17322376 | pubmed:author | pubmed-author:BainbridgeSha... | lld:pubmed |
| pubmed-article:17322376 | pubmed:author | pubmed-author:DickinsonMich... | lld:pubmed |
| pubmed-article:17322376 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17322376 | pubmed:volume | 170 | lld:pubmed |
| pubmed-article:17322376 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17322376 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17322376 | pubmed:pagination | 909-20 | lld:pubmed |
| pubmed-article:17322376 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
| pubmed-article:17322376 | pubmed:meshHeading | pubmed-meshheading:17322376... | lld:pubmed |
