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rdf:type |
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lifeskim:mentions |
umls-concept:C0009324,
umls-concept:C0017262,
umls-concept:C0026724,
umls-concept:C0030705,
umls-concept:C0033684,
umls-concept:C1166795,
umls-concept:C1171362,
umls-concept:C1334536,
umls-concept:C1412854,
umls-concept:C1416959,
umls-concept:C1515670,
umls-concept:C1708842
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pubmed:issue |
12
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pubmed:dateCreated |
2007-11-28
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pubmed:abstractText |
Long term ulcerative colitis (UC) increases the risk of colorectal cancer (CRC). DNA aneuploidy is a common feature of both dysplastic and non-dysplastic colonic epithelia from patients with longstanding UC, and is regarded as an early sign of possible malignant transformation. The spindle proteins Aurora A, BUB1B and Mad2 have been implicated as contributors to aneuploidy and carcinogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bub1 spindle checkpoint protein,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MAD2L1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/aurora kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1472-4146
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1403-8
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pubmed:dateRevised |
2011-7-11
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pubmed:meshHeading |
pubmed-meshheading:17322345-Calcium-Binding Proteins,
pubmed-meshheading:17322345-Cell Cycle Proteins,
pubmed-meshheading:17322345-Colectomy,
pubmed-meshheading:17322345-Colitis, Ulcerative,
pubmed-meshheading:17322345-Colonic Neoplasms,
pubmed-meshheading:17322345-DNA, Neoplasm,
pubmed-meshheading:17322345-Disease Progression,
pubmed-meshheading:17322345-Humans,
pubmed-meshheading:17322345-Intestinal Mucosa,
pubmed-meshheading:17322345-Ki-67 Antigen,
pubmed-meshheading:17322345-Neoplasm Proteins,
pubmed-meshheading:17322345-Ploidies,
pubmed-meshheading:17322345-Precancerous Conditions,
pubmed-meshheading:17322345-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17322345-Repressor Proteins,
pubmed-meshheading:17322345-Tumor Markers, Biological
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pubmed:year |
2007
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pubmed:articleTitle |
Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis.
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pubmed:affiliation |
The Pathology Clinic, Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, Faculty of Medicine, Oslo, Norway. espen.burum-auensen@medisin.uio.no
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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