|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003250,
umls-concept:C0019080,
umls-concept:C0021031,
umls-concept:C0034693,
umls-concept:C0035647,
umls-concept:C0040053,
umls-concept:C0205314,
umls-concept:C0332255,
umls-concept:C0392756,
umls-concept:C0679622,
umls-concept:C1515655
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2007-4-19
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|
pubmed:abstractText |
Inhibition of GPVI has been proposed as a useful antithrombotic strategy; however, in vivo proof-of-concept animal studies targeting GPVI are lacking. We evaluated a novel anti-human GPVI monoclonal antibody OM4 Fab in rats.
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|
pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
May
|
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pubmed:issn |
1524-4636
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|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1199-205
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pubmed:meshHeading |
pubmed-meshheading:17322098-Animals,
pubmed-meshheading:17322098-Antibodies, Monoclonal,
pubmed-meshheading:17322098-Bleeding Time,
pubmed-meshheading:17322098-Blotting, Western,
pubmed-meshheading:17322098-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:17322098-Hemorrhage,
pubmed-meshheading:17322098-Immunoglobulin Fab Fragments,
pubmed-meshheading:17322098-Immunoglobulin G,
pubmed-meshheading:17322098-Incidence,
pubmed-meshheading:17322098-Injections, Intravenous,
pubmed-meshheading:17322098-Platelet Aggregation,
pubmed-meshheading:17322098-Platelet Count,
pubmed-meshheading:17322098-Platelet Membrane Glycoproteins,
pubmed-meshheading:17322098-Rats,
pubmed-meshheading:17322098-Risk Factors,
pubmed-meshheading:17322098-Thrombosis
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
The Fab fragment of a novel anti-GPVI monoclonal antibody, OM4, reduces in vivo thrombosis without bleeding risk in rats.
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|
pubmed:affiliation |
Department of Cardiology and Thrombosis, Otsuka Maryland Medicinal Laboratories Inc, 9900 Medical Center Drive, Rockville, MD 20850, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
