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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1992-2-25
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pubmed:abstractText |
The three-dimensional solution structure of the repeating -PO4-6Gal beta 1-4Man alpha 1- disaccharide fragment of the lipophosphoglycan (LPG) derived from Leishmania donovani has been determined by use of a combination of homo- and heteronuclear NMR spin coupling constant measurements together with restrained molecular mechanical minimization and molecular dynamics simulations. The fragment exists with limited mobility in solution about the Gal beta 1-4Man linkages, whereas in contrast a variety of stable rotamers exist about the Man alpha 1-PO4-6Gal linkages. These rotamers define several major stable conformers in solution, which are discussed in terms of the proposed biological role of LPG.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-2960
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
654-61
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:1731920-Animals,
pubmed-meshheading:1731920-Carbohydrate Conformation,
pubmed-meshheading:1731920-Carbohydrate Sequence,
pubmed-meshheading:1731920-Glycosphingolipids,
pubmed-meshheading:1731920-Leishmania donovani,
pubmed-meshheading:1731920-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1731920-Mathematics,
pubmed-meshheading:1731920-Models, Molecular,
pubmed-meshheading:1731920-Molecular Conformation,
pubmed-meshheading:1731920-Molecular Sequence Data,
pubmed-meshheading:1731920-Thermodynamics
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pubmed:year |
1992
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pubmed:articleTitle |
Solution structure of the lipophosphoglycan of Leishmania donovani.
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pubmed:affiliation |
Department of Biochemistry, University of Dundee, Scotland, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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