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pubmed-article:17318877pubmed:abstractTextSubstantial evidence supports a direct role of ornithine decarboxylase (ODC) in the development and maintenance of human tumors. Although antisense oligonucleotide therapy targeting various genes are useful for cancer treatment, 1 of the major limitations is the problem of delivery. A novel antisense oligonucleotide delivery method is described that allows prolonged sustainment and release of ODC antisense oligonucleotides in vivo using atelocollagen.lld:pubmed
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pubmed-article:17318877pubmed:articleTitleSingle-injection ornithine decarboxylase-directed antisense therapy using atelocollagen to suppress human cancer growth.lld:pubmed
pubmed-article:17318877pubmed:affiliationDepartment of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.lld:pubmed
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