|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2007-3-29
|
|
pubmed:abstractText |
DNA topoisomerases utilize a covalent complex formed after DNA cleavage as an intermediate in the interconversion of topological forms via DNA cleavage and religation. Many anticancer and antibacterial therapeutic agents are effective because they stabilize or increase the level of the covalent topoisomerase-DNA complex formed by type IIA or type IB topoisomerases. Our goal is to identify small molecules that can enhance DNA cleavage by type IA DNA topoisomerase. Compounds that act in this mechanism against type IA topoisomerase have not been identified previously and could be leads for development of a new class of antibacterial agents.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0305-7453
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
59
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
640-5
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17317696-Anti-Bacterial Agents,
pubmed-meshheading:17317696-Bacillus subtilis,
pubmed-meshheading:17317696-DNA, Bacterial,
pubmed-meshheading:17317696-Drug Design,
pubmed-meshheading:17317696-Drug Evaluation, Preclinical,
pubmed-meshheading:17317696-Enzyme Induction,
pubmed-meshheading:17317696-Enzyme Inhibitors,
pubmed-meshheading:17317696-Escherichia coli,
pubmed-meshheading:17317696-Genes, Reporter,
pubmed-meshheading:17317696-Luciferases,
pubmed-meshheading:17317696-Plasmids,
pubmed-meshheading:17317696-Topoisomerase I Inhibitors,
pubmed-meshheading:17317696-Vaccinia,
pubmed-meshheading:17317696-Yersinia pestis
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Compounds with antibacterial activity that enhance DNA cleavage by bacterial DNA topoisomerase I.
|
|
pubmed:affiliation |
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
