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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0020564,
umls-concept:C0035696,
umls-concept:C0086661,
umls-concept:C0087140,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0332120,
umls-concept:C0441889,
umls-concept:C1882854,
umls-concept:C2911684
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pubmed:dateCreated |
1992-2-18
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pubmed:abstractText |
The levels of c-myc and c-fos mRNA were investigated in rat skeletal muscle by Northern hybridization. During post-natal development in the rat, c-myc mRNA levels were similar at birth and at 7 and 21 days of age, but then declined at 90 days and were barely detectable at 1 year. c-fos mRNA levels followed this pattern of expression until 90 days, but showed a large increase at 1 year. Hypertrophy of soleus and plantaris muscles was induced either by severance of the tendon to the synergistic gastrocnemius (tenotomy) or by administration of the beta-adrenoceptor agonist clenbuterol. In both cases hypertrophy was associated with a rapid increase in c-myc mRNA levels. Following tenotomy the increase was both greater (8-fold) and more rapid (3 h) in soleus than in plantaris (2-3 fold, 12 h). Similar effects were observed during clenbuterol administration. Neither treatment caused any alteration in c-fos mRNA levels in the plantaris muscle. The results show that increased c-myc mRNA levels are an early event in the response of skeletal muscle to hypertrophic stimuli; it is argued that this occurs within the differentiated skeletal muscle fibres.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-1694017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2372054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2431278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2447874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2454393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2454761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2477284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2493990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2539093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2651181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2942194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2958008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-2963328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-3022291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-3077064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-3175662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-3314392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-3841511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-4265520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-6282683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-6292525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-6692471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-728992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1731749-861188
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
281 ( Pt 1)
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pubmed:geneSymbol |
c-fos,
c-myc
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
143-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1731749-Aging,
pubmed-meshheading:1731749-Animals,
pubmed-meshheading:1731749-Blotting, Northern,
pubmed-meshheading:1731749-Clenbuterol,
pubmed-meshheading:1731749-Female,
pubmed-meshheading:1731749-Gene Expression,
pubmed-meshheading:1731749-Genes, fos,
pubmed-meshheading:1731749-Genes, myc,
pubmed-meshheading:1731749-Hypertrophy,
pubmed-meshheading:1731749-Muscle Development,
pubmed-meshheading:1731749-Muscles,
pubmed-meshheading:1731749-RNA, Messenger,
pubmed-meshheading:1731749-RNA, Ribosomal, 18S,
pubmed-meshheading:1731749-Rats,
pubmed-meshheading:1731749-Rats, Inbred Strains,
pubmed-meshheading:1731749-Tendons
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pubmed:year |
1992
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pubmed:articleTitle |
Expression of c-myc and c-fos in rat skeletal muscle. Evidence for increased levels of c-myc mRNA during hypertrophy.
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pubmed:affiliation |
Division of Biochemical Sciences, Rowett Research Institute, Bucksburn, Aberdeen, U.K.
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pubmed:publicationType |
Journal Article
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