Source:http://linkedlifedata.com/resource/pubmed/id/17316909
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2007-6-1
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pubmed:abstractText |
Amiodarone (AMI) is a potent antiarrhythmic agent; however, its clinical use is limited due to numerous side effects. In order to investigate the structure--cytotoxicity relationship, AMI analogues were synthesized, and then, using rabbit alveolar macrophages, were tested for viability and for the ability to interfere with the degradation of surfactant protein A (SP-A) and with the accumulation of an acidotropic dye. Our data revealed that modification of the diethylamino-beta-ethoxy group of the AMI molecule may affect viability, the ability to degrade SP-A and vacuolation differently. In particular, PIPAM (2d), an analogue with a piperidyl moiety, acts toward the cells in a similar manner to AMI, but is less toxic. Thus, it would be possible to reduce the cytotoxicity of AMI by modifying its chemical structure.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0223-5234
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
861-7
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pubmed:meshHeading |
pubmed-meshheading:17316909-Amiodarone,
pubmed-meshheading:17316909-Animals,
pubmed-meshheading:17316909-Antineoplastic Agents,
pubmed-meshheading:17316909-Humans,
pubmed-meshheading:17316909-Macrophages, Alveolar,
pubmed-meshheading:17316909-Molecular Structure,
pubmed-meshheading:17316909-Pulmonary Surfactants,
pubmed-meshheading:17316909-Rabbits
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis and cytotoxicity properties of amiodarone analogues.
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pubmed:affiliation |
Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
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pubmed:publicationType |
Journal Article
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