Linked Life Data

17316857

Source:http://linkedlifedata.com/resource/pubmed/id/17316857

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-6-5
pubmed:abstractText
Generation of knockout mice with targeted mutations in desired genes is one of the most important technologies available for determining the functions of gene products in the brain. However, conventional knockout technology has limitations, such as when conventional knockout results in a lethal phenotype or when gene function at a certain developmental stage must be elucidated. To circumvent these limitations, a tetracycline-controlled gene expression system has been exploited to generate conditional mutant mice in which expression of desired genes can be switched on or off by oral administration of tetracycline derivatives. This up-date article introduces conditional mutant mice obtained using the tetracycline-controlled gene expression system, and presents several examples including our versatile mouse line, the mGluR1 conditional knockout mouse.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0168-0102
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Conditional mutant mice using tetracycline-controlled gene expression system in the brain.
pubmed:affiliation
Division of Cell Biology, Department of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. aiba@med.kobe-u.ac.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't