Linked Life Data

17316080

Source:http://linkedlifedata.com/resource/pubmed/id/17316080

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-2-23
pubmed:abstractText
The potential for experimental immunotherapy of colorectal cancers by mouse IgG2a monoclonal antibody (MAb) ND4 is investigated. The MAb ND4 recognizes a 160 kd cell surface glycoprotein that is strongly expressed in 58% of colorectal carcinomas. The antibody is internalizable by MIP-101 colorectal carcinoma cells. Biodistribution studies in nude mice bearing MIP-101 subcutaneous tumors showed accumulation of 125I-ND4 MAb in tumors from 5% at 18 hours to 14% of the injected dose per gram tissue at 14 days after intraperitoneal (i.p.) injection. Experimental immunotherapy studies using 125I-ND4 in MIP-101 tumor-bearing nude mice showed 64% inhibition of tumor growth 2 weeks after two i.p. injections at 7-day intervals. The MAb ND4 may be useful as a therapeutic reagent for colorectal tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1554-0014
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10-6
pubmed:dateRevised
2008-5-28
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Experimental immunotherapy of colorectal carcinoma by monoclonal antibody ND4.
pubmed:affiliation
Department of Surgery, Laboratory of Cancer Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA.
pubmed:publicationType
Journal Article