Source:http://linkedlifedata.com/resource/pubmed/id/17315957
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2007-2-23
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pubmed:abstractText |
Nine new triterpene glycosides, erylosides F1-F4 (1-4), M (5), N (6), O (7), P (8), and Q (9), along with previously known erylosides F (10) and H (11) were isolated from the sponge Erylus formosus collected from the Mexican Gulf (Puerto Morelos, Mexico). Structures of 1-4 were determined as the corresponding biosides having aglycons related to penasterol with additional oxidation patterns in their side chains. Erylosides 5-9 contain new variants of carbohydrate chains with three (5, 6), four (7), and six (8, 9) sugar units, respectively. Erylosides 5, 7, 8, and 6, 9 contain 14-carboxy-24-methylenelanost-8(9)-en-3beta-ol and penasterol as aglycons, respectively. In contrast with its epimer 2, the compound 3 induced the early apoptosis of Ehrlich carcinoma cells at a concentration of 100 microg/mL, while 1 and 10 activated the Ca2+ influx into mouse spleenocytes (130% of the control) at the same doses.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosides,
http://linkedlifedata.com/resource/pubmed/chemical/Saponins,
http://linkedlifedata.com/resource/pubmed/chemical/Triterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/eryloside F
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0163-3864
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-78
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pubmed:meshHeading |
pubmed-meshheading:17315957-Animals,
pubmed-meshheading:17315957-Antineoplastic Agents,
pubmed-meshheading:17315957-Apoptosis,
pubmed-meshheading:17315957-Carcinoma, Ehrlich Tumor,
pubmed-meshheading:17315957-Caribbean Region,
pubmed-meshheading:17315957-Drug Screening Assays, Antitumor,
pubmed-meshheading:17315957-Glycosides,
pubmed-meshheading:17315957-Mice,
pubmed-meshheading:17315957-Molecular Structure,
pubmed-meshheading:17315957-Porifera,
pubmed-meshheading:17315957-Saponins,
pubmed-meshheading:17315957-Spleen,
pubmed-meshheading:17315957-Triterpenes
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pubmed:year |
2007
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pubmed:articleTitle |
Isolation and structures of erylosides from the Caribbean sponge Erylus formosus.
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pubmed:affiliation |
Laboratory of the MaNaPro Chemistry, Pacific Institute of Bioorganic Chemistry, Vladivostok-22, Russian Federation.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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