Linked Life Data

17315855

Source:http://linkedlifedata.com/resource/pubmed/id/17315855

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:17315855rdf:typepubmed:Citationlld:pubmed
pubmed-article:17315855lifeskim:mentionsumls-concept:C0003805lld:lifeskim
pubmed-article:17315855lifeskim:mentionsumls-concept:C1512505lld:lifeskim
pubmed-article:17315855lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:17315855lifeskim:mentionsumls-concept:C0220781lld:lifeskim
pubmed-article:17315855lifeskim:mentionsumls-concept:C0220825lld:lifeskim
pubmed-article:17315855lifeskim:mentionsumls-concept:C1883254lld:lifeskim
pubmed-article:17315855lifeskim:mentionsumls-concept:C0182953lld:lifeskim
pubmed-article:17315855lifeskim:mentionsumls-concept:C0205460lld:lifeskim
pubmed-article:17315855lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:17315855lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:17315855pubmed:issue7lld:pubmed
pubmed-article:17315855pubmed:dateCreated2007-3-29lld:pubmed
pubmed-article:17315855pubmed:abstractTextAromatase converts androgens to estrogens and is a particularly attractive target in the treatment of estrogen receptor positive breast cancer. The enzyme is encoded by the CYP19 gene, which is expressed in a tissue-specific manner. Prostaglandin E2 (PGE2), the major product of cyclooxygenase-2 (COX-2), stimulates aromatase gene expression via protein kinase A and C signaling pathways. Our previous study demonstrated that COX-2 selective inhibitor nimesulide decreased aromatase activity from the transcriptional level in breast cancer cells. In this manuscript, the synthesis and biological evaluation of a series of nimesulide analogues as potential selective aromatase expression regulators are described. Several novel sulfonanilide compounds demonstrate IC50 values from 0.33 to 2.68 microM in suppressing aromatase enzyme activity in SK-BR-3 breast cancer cells and are 10- to 80-fold more active than nimesulide. Also, the sulfonanilide compounds selectively decrease aromatase gene expression in breast cancer cells, without exhibiting cytotoxic or apoptotic effects at low micromole concentrations.lld:pubmed
pubmed-article:17315855pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17315855pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17315855pubmed:languageenglld:pubmed
pubmed-article:17315855pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17315855pubmed:citationSubsetIMlld:pubmed
pubmed-article:17315855pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17315855pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17315855pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17315855pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17315855pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:17315855pubmed:statusMEDLINElld:pubmed
pubmed-article:17315855pubmed:monthAprlld:pubmed
pubmed-article:17315855pubmed:issn0022-2623lld:pubmed
pubmed-article:17315855pubmed:authorpubmed-author:JeE YEYlld:pubmed
pubmed-article:17315855pubmed:authorpubmed-author:BrueggemeierR...lld:pubmed
pubmed-article:17315855pubmed:authorpubmed-author:LandiniSerena...lld:pubmed
pubmed-article:17315855pubmed:authorpubmed-author:DavisDanyetta...lld:pubmed
pubmed-article:17315855pubmed:issnTypePrintlld:pubmed
pubmed-article:17315855pubmed:day5lld:pubmed
pubmed-article:17315855pubmed:volume50lld:pubmed
pubmed-article:17315855pubmed:ownerNLMlld:pubmed
pubmed-article:17315855pubmed:authorsCompleteYlld:pubmed
pubmed-article:17315855pubmed:pagination1635-44lld:pubmed
pubmed-article:17315855pubmed:dateRevised2011-9-22lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:meshHeadingpubmed-meshheading:17315855...lld:pubmed
pubmed-article:17315855pubmed:year2007lld:pubmed
pubmed-article:17315855pubmed:articleTitleSynthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells.lld:pubmed
pubmed-article:17315855pubmed:affiliationDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, and Ohio State Biochemistry Program, The Ohio State University, 500 W. 12th Avenue, Columbus, Ohio 43210, USA.lld:pubmed
pubmed-article:17315855pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17315855pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:17315855pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
http://linkedlifedata.com/r...http://linkedlifedata.com/r...pubmed-article:17315855lld:chembl
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17315855lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:17315855lld:pubmed