Source:http://linkedlifedata.com/resource/pubmed/id/17315164
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2007-3-28
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| pubmed:abstractText |
Sex steroid hormones play a central role in the development of endometrial cancer. Sex hormone-binding globulin (SHBG) modulates the bioavailability of circulating sex hormones and regulates their signaling systems in target cells. Epidemiologic studies have demonstrated that blood SHBG levels are associated inversely with the risk of endometrial cancer. A functional polymorphism, an amino acid substitution of asparagine (Asp) for aspartic acid (Asn) at residue 327 (Asp(327)Asn) (reference sequence 6259), in the SHBG gene recently was identified and has been associated with an increased half-life and elevated blood levels of SHBG. The authors tested the hypothesis that this genetic variance is associated with a reduced risk of endometrial cancer in the Shanghai Endometrial Cancer Study, a population-based, case-control study that was conducted in urban Shanghai, China between 1997 and 2003.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0008-543X
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| pubmed:author | |
| pubmed:copyrightInfo |
(c) 2007 American Cancer Society.
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| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
109
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1296-302
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| pubmed:dateRevised |
2007-12-3
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| pubmed:meshHeading |
pubmed-meshheading:17315164-Adult,
pubmed-meshheading:17315164-Aged,
pubmed-meshheading:17315164-Body Mass Index,
pubmed-meshheading:17315164-Case-Control Studies,
pubmed-meshheading:17315164-China,
pubmed-meshheading:17315164-Endometrial Neoplasms,
pubmed-meshheading:17315164-Female,
pubmed-meshheading:17315164-Genetic Predisposition to Disease,
pubmed-meshheading:17315164-Genotype,
pubmed-meshheading:17315164-Humans,
pubmed-meshheading:17315164-Middle Aged,
pubmed-meshheading:17315164-Polymerase Chain Reaction,
pubmed-meshheading:17315164-Polymorphism, Genetic,
pubmed-meshheading:17315164-Postmenopause,
pubmed-meshheading:17315164-Premenopause,
pubmed-meshheading:17315164-Receptors, Estrogen,
pubmed-meshheading:17315164-Registries,
pubmed-meshheading:17315164-Risk Factors,
pubmed-meshheading:17315164-Sex Hormone-Binding Globulin
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| pubmed:year |
2007
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| pubmed:articleTitle |
Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene.
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| pubmed:affiliation |
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|