Linked Life Data

17314673

Source:http://linkedlifedata.com/resource/pubmed/id/17314673

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pubmed-article:17314673pubmed:abstractTextPrior transcranial magnetic stimulation studies showed that resting motor threshold is elevated in abstinent cocaine-dependent patients, suggesting a decrease in axonal excitability. In contrast, the increased incidence of seizures and psychosis in this group suggests increased excitability or decreased inhibition. Here, we studied long-interval intracortical facilitation and long-interval intracortical inhibition, paired-pulse transcranial magnetic stimulation measures that are more directly linked to glutamatergic cortical facilitation and GABAergic inhibition, respectively. Ten cocaine-dependent and 10 healthy controls were examined. Resting motor threshold, long-interval intracortical facilitation and long-interval intracortical inhibition were tested from the left motor cortex. The cocaine group showed an elevated resting motor threshold and an increased long-interval intracortical facilitation, whereas long-interval intracortical inhibition was normal. Although the increase in long-interval intracortical facilitation suggests exaggerated cortical glutamatergic excitability, the increase in resting motor threshold may signify a protective mechanism against seizures and psychosis.lld:pubmed
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pubmed-article:17314673pubmed:pagination289-92lld:pubmed
pubmed-article:17314673pubmed:dateRevised2007-12-3lld:pubmed
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pubmed-article:17314673pubmed:articleTitleCortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study.lld:pubmed
pubmed-article:17314673pubmed:affiliationDepartment of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, USA.lld:pubmed
pubmed-article:17314673pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17314673pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed