Source:http://linkedlifedata.com/resource/pubmed/id/17314673
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2007-2-22
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| pubmed:abstractText |
Prior transcranial magnetic stimulation studies showed that resting motor threshold is elevated in abstinent cocaine-dependent patients, suggesting a decrease in axonal excitability. In contrast, the increased incidence of seizures and psychosis in this group suggests increased excitability or decreased inhibition. Here, we studied long-interval intracortical facilitation and long-interval intracortical inhibition, paired-pulse transcranial magnetic stimulation measures that are more directly linked to glutamatergic cortical facilitation and GABAergic inhibition, respectively. Ten cocaine-dependent and 10 healthy controls were examined. Resting motor threshold, long-interval intracortical facilitation and long-interval intracortical inhibition were tested from the left motor cortex. The cocaine group showed an elevated resting motor threshold and an increased long-interval intracortical facilitation, whereas long-interval intracortical inhibition was normal. Although the increase in long-interval intracortical facilitation suggests exaggerated cortical glutamatergic excitability, the increase in resting motor threshold may signify a protective mechanism against seizures and psychosis.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0959-4965
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
12
|
| pubmed:volume |
18
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
289-92
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| pubmed:dateRevised |
2007-12-3
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| pubmed:meshHeading |
pubmed-meshheading:17314673-Adult,
pubmed-meshheading:17314673-Brain,
pubmed-meshheading:17314673-Cocaine,
pubmed-meshheading:17314673-Cocaine-Related Disorders,
pubmed-meshheading:17314673-Dopamine Uptake Inhibitors,
pubmed-meshheading:17314673-Evoked Potentials, Motor,
pubmed-meshheading:17314673-Excitatory Postsynaptic Potentials,
pubmed-meshheading:17314673-Female,
pubmed-meshheading:17314673-Glutamic Acid,
pubmed-meshheading:17314673-Humans,
pubmed-meshheading:17314673-Male,
pubmed-meshheading:17314673-Middle Aged,
pubmed-meshheading:17314673-Motor Cortex,
pubmed-meshheading:17314673-Neural Inhibition,
pubmed-meshheading:17314673-Substance Withdrawal Syndrome,
pubmed-meshheading:17314673-Synaptic Transmission,
pubmed-meshheading:17314673-Transcranial Magnetic Stimulation,
pubmed-meshheading:17314673-gamma-Aminobutyric Acid
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Cortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study.
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| pubmed:affiliation |
Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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