Linked Life Data

17313446

Source:http://linkedlifedata.com/resource/pubmed/id/17313446

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-4-3
pubmed:abstractText
Graft-versus-host disease continues to be a major life-threatening complication after allogeneic hematopoietic stem cells transplantation (aHSCT). The relationship of acute GVHD (aGVHD) with the levels of peripheral CD4(+)CD25(high) T cells in patients after aHSCT and in their corresponding donors is not fully investigated. We examined the levels of CD4(+)CD25(high) T cells in patients after aHSCT and in their corresponding donors, and analyzed the relationship of CD4(+)CD25(high) T cells to the incidence and prognosis of aGVHD. The recipients with normal or high CD4(+)CD25(high) T cells (three of eight, 37.5%) had no or mild aGVHD (grade I), and all survived during the follow-up period. In striking contrast, the recipients with lower or no CD4(+)CD25(high) T cells suffered from greater than grade II aGVHD (four of four, 100%), and all died within 1-year post-aHSCT. Moreover, the number of CD4(+)CD25(high) T cells in recipients correlated significantly with that of their corresponding donors. The CD4(+)CD25(high) T cells from the recipients and their corresponding donors expressed high levels of Foxp3, and effectively suppressed the proliferation of CD4(+)CD25(-) responder T cells. This study suggests that human Treg cells may play an important role in aGVHD, as has been seen in murine models. The levels of peripheral CD4(+)CD25(high) T cells in recipients and donors could be helpful for predicting of the onset and outcome of aGVHD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0934-0874
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
440-6
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Correlation of the CD4+CD25high T-regulatory cells in recipients and their corresponding donors to acute GVHD.
pubmed:affiliation
The Center of Stem Cell Research and Therapy in the Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei City, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't