| pubmed-article:17313444 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17313444 | lifeskim:mentions | umls-concept:C0002092 | lld:lifeskim |
| pubmed-article:17313444 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:17313444 | lifeskim:mentions | umls-concept:C0111208 | lld:lifeskim |
| pubmed-article:17313444 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:17313444 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:17313444 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:17313444 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:17313444 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:17313444 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:17313444 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:17313444 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17313444 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17313444 | pubmed:dateCreated | 2007-4-11 | lld:pubmed |
| pubmed-article:17313444 | pubmed:abstractText | T helper type 2 (Th2) cell differentiation requires the expression of GATA-3, a transcription factor that allows transcriptional activation of Th2 cytokine genes through chromatin remodelling. We investigated the role of the negative costimulatory receptor cytotoxic T-lymphocyte antigen 4 (CTLA-4) in the regulation of GATA-3 expression, Th2 differentiation and immunoglobulin production during the immune response to allergens. BALB/c mice were immunized with a recombinant major allergenic component of Parietaria judaica pollen, rPar j I, and treated with blocking anti-CTLA-4 or control antibodies. Results showed that in vivo CTLA-4 blockade enhanced the Par j I-specific immunoglobulin E (IgE) serum level. In contrast, Par j I-specific IgG2a serum level was reduced, suggesting that CTLA-4 blockade skewed immunoglobulin production towards interleukin-4 (IL-4) -dependent immunoglobulin isotypes. Consistently, CTLA-4 blockade increased the frequency of Par j I-specific Th2 cells but not Th1 cells, as well as IL-4 and IL-5 but not interferon-gamma production. Our data also showed that CTLA-4 blockade enhanced the GATA-3 : T-bet messenger RNA ratio. Interestingly, in vivo CTLA-4 blockade did not increase the frequency of GATA-3 protein-expressing cells. In contrast, it enhances GATA-3 protein level per cell. Further, in vitro results show that the anti-CTLA-4 monoclonal antibody, by competing with CD80 for CTLA-4 binding, induced an enhancement in the frequency of IL-4-producing cells that correlates with the increase in GATA-3 protein level per cell. In conclusion, CTLA-4, by affecting the level of GATA-3 per cell, contributes to keeping this factor under the threshold required to become a Th2 effector cell. Consequently, it affects IgE/IgG2a production and contributes to the outcome of allergen-specific immune responses. | lld:pubmed |
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| pubmed-article:17313444 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17313444 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17313444 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17313444 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17313444 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17313444 | pubmed:month | May | lld:pubmed |
| pubmed-article:17313444 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:17313444 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:17313444 | pubmed:author | pubmed-author:CorintiSilvia... | lld:pubmed |
| pubmed-article:17313444 | pubmed:author | pubmed-author:ColomboPaoloP | lld:pubmed |
| pubmed-article:17313444 | pubmed:author | pubmed-author:PioliClaudioC | lld:pubmed |
| pubmed-article:17313444 | pubmed:author | pubmed-author:BonuraAngelaA | lld:pubmed |
| pubmed-article:17313444 | pubmed:author | pubmed-author:NastaFrancesc... | lld:pubmed |
| pubmed-article:17313444 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17313444 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:17313444 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17313444 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17313444 | pubmed:pagination | 62-70 | lld:pubmed |
| pubmed-article:17313444 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
