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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1976-3-1
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pubmed:abstractText |
Spinal ganglia from a patient who died on the 6th day of varicella infection were examined by immunofluorescence and electron microscopy, and were compared with spinal ganglia from a patient dying on the 17th day of herpes zoster infection. In herpes zoster, typical intranuclear inclusion bodies were found in neurons, satellite cells and fibroblast-like cells of the ganglia, which contained numerous naked virus particles. In varicella, few changes were found by light microscopy but viral antigen was detected in a few neurons and satellite cells by immunofluorescence. Electron microscopy revealed scattered virus particles near the nuclear membrane of a neuron, satellite cells and capsular cells and enveloped particles in the cytoplasm of satellite cells. The particles in the nuclei were mostly naked virions with specific crescent-like inner-nuclear structure; those in the cytoplasm had complete and incomplete envelopes and showed pleomorphism. A "virus-like" intranuclear filament found in mononuclear cells in herpes zoster and a "plexiform vermicellar array" found in the nuclei of neurons in varicella are at present considered to be non-specific nuclear changes caused probably by viral infections.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0001-6322
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
8
|
pubmed:volume |
33
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
105-17
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pubmed:dateRevised |
2007-11-9
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pubmed:meshHeading |
pubmed-meshheading:173126-Adult,
pubmed-meshheading:173126-Antigens, Viral,
pubmed-meshheading:173126-Cell Nucleus,
pubmed-meshheading:173126-Chickenpox,
pubmed-meshheading:173126-Child,
pubmed-meshheading:173126-Demyelinating Diseases,
pubmed-meshheading:173126-Female,
pubmed-meshheading:173126-Fibroblasts,
pubmed-meshheading:173126-Fluorescent Antibody Technique,
pubmed-meshheading:173126-Ganglia, Spinal,
pubmed-meshheading:173126-Hemorrhage,
pubmed-meshheading:173126-Herpes Zoster,
pubmed-meshheading:173126-Herpesvirus 3, Human,
pubmed-meshheading:173126-Humans,
pubmed-meshheading:173126-Inclusion Bodies, Viral,
pubmed-meshheading:173126-Male,
pubmed-meshheading:173126-Neurons,
pubmed-meshheading:173126-Skin
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pubmed:year |
1975
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pubmed:articleTitle |
Pathology of the human spinal ganglia in varicella-zoster virus infection.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|