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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-2-21
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pubmed:abstractText |
Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance. In particular, patients with Lynch syndrome, hereditary nonpolyposis colorectal cancer (HNPCC), have an increased risk to develop colorectal cancer at an early age. The syndrome is explained by germline mutations in DNA mismatch repair (MMR) genes, and there is a need for diagnostic tools to preselect patients for genetic testing to diagnose those with HNPCC.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/BRAF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Repair Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/G-T mismatch-binding protein,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PMS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins B-raf
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1460-2105
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pubmed:author |
pubmed-author:ClendenningMarkM,
pubmed-author:FrebourgThierryT,
pubmed-author:HalvarssonBrittaB,
pubmed-author:KinzlerKenneth WKW,
pubmed-author:KolodnerRichard DRD,
pubmed-author:Lagerstedt RobinsonKristinaK,
pubmed-author:LindblomAnnikaA,
pubmed-author:NilbertMefM,
pubmed-author:PapadopoulosNickolasN,
pubmed-author:PeltomäkiPäiviP,
pubmed-author:VandrovcovaJanaJ,
pubmed-author:VogelsteinBertB,
pubmed-author:ZAKR LRL
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
291-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17312306-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:17312306-Adenosine Triphosphatases,
pubmed-meshheading:17312306-Adult,
pubmed-meshheading:17312306-Carrier Proteins,
pubmed-meshheading:17312306-Colorectal Neoplasms, Hereditary Nonpolyposis,
pubmed-meshheading:17312306-DNA Mismatch Repair,
pubmed-meshheading:17312306-DNA Repair Enzymes,
pubmed-meshheading:17312306-DNA-Binding Proteins,
pubmed-meshheading:17312306-Decision Trees,
pubmed-meshheading:17312306-Diagnosis, Differential,
pubmed-meshheading:17312306-Female,
pubmed-meshheading:17312306-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17312306-Genetic Predisposition to Disease,
pubmed-meshheading:17312306-Germ-Line Mutation,
pubmed-meshheading:17312306-Humans,
pubmed-meshheading:17312306-Immunohistochemistry,
pubmed-meshheading:17312306-Male,
pubmed-meshheading:17312306-Microsatellite Instability,
pubmed-meshheading:17312306-Middle Aged,
pubmed-meshheading:17312306-MutS Homolog 2 Protein,
pubmed-meshheading:17312306-Mutation, Missense,
pubmed-meshheading:17312306-Nuclear Proteins,
pubmed-meshheading:17312306-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:17312306-Retrospective Studies
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pubmed:year |
2007
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pubmed:articleTitle |
Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics.
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pubmed:affiliation |
Department of Clinical Genetics, Karolinska University Hospital, S-17176 Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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