Linked Life Data

17311943

Source:http://linkedlifedata.com/resource/pubmed/id/17311943

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-2-21
pubmed:abstractText
The scavenger receptor class B type I (SCARB1) is a cell surface glycoprotein that plays a key role in reverse cholesterol transport. A polymorphism in exon 8 (c.1119C>T) has been associated with fasting HDL- and LDL- cholesterol concentrations in Caucasian populations. This study evaluated whether this variant is associated with postprandial lipemia in 59 normolipidemic males. After an overnight fast, the subjects were given a single fat load comprising 60% of energy as fat, 15% as protein, and 25% as carbohydrate. Blood was drawn every hour from baseline to 6 h, then every 2.5 h until h 11. We measured plasma lipid concentrations including triglycerides (TG) in large and small triglyceride rich lipoprotein particles (TRL). Changes in postprandial small TRL TG differed among groups over time (Pgeno x time = 0.034) whereby TT and CT subjects maintained lower concentrations throughout most of the postprandial period compared with CC subjects. Significant differences occurred at h 1, 2, 4, and 5 (P < 0.05). Postprandial changes in large TRL TG (Pgeno x time = 0.923) or total TG (Pgeno x time = 0.529) did not differ by genotype. These results suggest that the c.1119C>T polymorphism is associated with a lower postprandial TG response in the smaller, partially catabolized lipoprotein fraction.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
137
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
578-82
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Scavenger receptor class B type I (SCARB1) c.1119C>T polymorphism affects postprandial triglyceride metabolism in men.
pubmed:affiliation
Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA. toshiko.tanaka@tufts.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural