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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-4-26
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pubmed:abstractText |
Schizophrenic patients show decreased measures of sensorimotor gating, such as prepulse inhibition of startle (PPI). In preclinical models, these measures may be used to predict antipsychotic activity. While current antipsychotic drugs act largely at dopamine receptors, the muscarinic acetylcholine receptors offer promising novel pharmacotherapy targets. Of these, the M(5) receptor gene was recently implicated in susceptibility to schizophrenia. Due to the lack of selective ligands, muscarinic receptor knockout mice have been generated to elucidate the roles of the five receptor subtypes (M(1)-M(5)).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
192
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-110
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17310388-Animals,
pubmed-meshheading:17310388-Antipsychotic Agents,
pubmed-meshheading:17310388-Behavior, Animal,
pubmed-meshheading:17310388-Clozapine,
pubmed-meshheading:17310388-Cocaine,
pubmed-meshheading:17310388-Dextroamphetamine,
pubmed-meshheading:17310388-Dopamine Agonists,
pubmed-meshheading:17310388-Female,
pubmed-meshheading:17310388-Genotype,
pubmed-meshheading:17310388-Haloperidol,
pubmed-meshheading:17310388-Male,
pubmed-meshheading:17310388-Mice,
pubmed-meshheading:17310388-Mice, Inbred C57BL,
pubmed-meshheading:17310388-Mice, Knockout,
pubmed-meshheading:17310388-Motor Activity,
pubmed-meshheading:17310388-Muscarinic Agonists,
pubmed-meshheading:17310388-Receptors, Muscarinic,
pubmed-meshheading:17310388-Reflex,
pubmed-meshheading:17310388-Schizophrenia,
pubmed-meshheading:17310388-Startle Reaction,
pubmed-meshheading:17310388-Trihexyphenidyl
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pubmed:year |
2007
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pubmed:articleTitle |
Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice.
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pubmed:affiliation |
Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. mthomsen@mclean.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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