| pubmed-article:1730874 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1730874 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1730874 | lifeskim:mentions | umls-concept:C0005773 | lld:lifeskim |
| pubmed-article:1730874 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:1730874 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1730874 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:1730874 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:1730874 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:1730874 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:1730874 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1730874 | pubmed:dateCreated | 1992-2-19 | lld:pubmed |
| pubmed-article:1730874 | pubmed:abstractText | We have identified and purified a factor that inhibits the production of IL-1 beta and TNF by stimulated human mononuclear cells. The activity is produced by the T cell lines Hut-78 and Mo constitutively under serum-free conditions. Crude conditioned media have titers of up to 100 U/ml (one unit defined as the reciprocal of the dilution producing 50% inhibition). The activity resides mainly in a single size peak of 30 to 35 kDa and an isoelectric point around 8. Other cytokines in this size range that have been reported to be inhibitory for IL-1 and TNF production include TGF-beta, IL-4, and IL-6; these factors were excluded by lack of detection, neutralizing antibody, and low activity compared with our factor. Another factor with these size and charge properties is IL-10, which inhibits T cell cytokine production. By polymerase chain reaction analysis, Mo and HuT-78 lines contain IL-10 transcripts whereas JURKAT is negative; this correlates with inhibitor bioactivity from the three lines. Use of mAb specifically showed the inhibitor to be IL-10. | lld:pubmed |
| pubmed-article:1730874 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1730874 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1730874 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1730874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1730874 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1730874 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1730874 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1730874 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1730874 | pubmed:author | pubmed-author:LimMM | lld:pubmed |
| pubmed-article:1730874 | pubmed:author | pubmed-author:RalphPP | lld:pubmed |
| pubmed-article:1730874 | pubmed:author | pubmed-author:FongSS | lld:pubmed |
| pubmed-article:1730874 | pubmed:author | pubmed-author:NakoinzII | lld:pubmed |
| pubmed-article:1730874 | pubmed:author | pubmed-author:LoweDD | lld:pubmed |
| pubmed-article:1730874 | pubmed:author | pubmed-author:DASS RSR | lld:pubmed |
| pubmed-article:1730874 | pubmed:author | pubmed-author:Sampson-Johan... | lld:pubmed |
| pubmed-article:1730874 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1730874 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1730874 | pubmed:volume | 148 | lld:pubmed |
| pubmed-article:1730874 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1730874 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1730874 | pubmed:pagination | 808-14 | lld:pubmed |
| pubmed-article:1730874 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1730874 | pubmed:meshHeading | pubmed-meshheading:1730874-... | lld:pubmed |
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| pubmed-article:1730874 | pubmed:meshHeading | pubmed-meshheading:1730874-... | lld:pubmed |
| pubmed-article:1730874 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1730874 | pubmed:articleTitle | IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor. | lld:pubmed |
| pubmed-article:1730874 | pubmed:affiliation | Department of Cell Biology, Cetus Corporation, Emeryville, CA 94608. | lld:pubmed |
| pubmed-article:1730874 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1730874 | pubmed:publicationType | In Vitro | lld:pubmed |
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