Linked Life Data

17308366

Source:http://linkedlifedata.com/resource/pubmed/id/17308366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-2-19
pubmed:abstractText
Bihormonal or plurihormonal pituitary tumors produce two or more hormones different in chemical composition, immunoreactivity, and clinical significance. Immunohistochemical and electron microscopic investigations and more recently molecular-genetic studies have provided conclusive evidence of the production of multiple hormones by pituitary adenomas. Most frequently, they produce GH, PRL, TSH, and/or alpha-subunit of the glycoprotein hormones. Other uncommon combinations may also be apparent. We report the case of a 40-yr-old acromegalic man with a pituitary macroadenoma. The pituitary tumor was removed by transsphenoidal surgery. Histological, immunohistochemical, electron microscopic, and immunoelectron microscopic examinations revealed that the tumor contains multiple hormones (GH, LH, and alpha subunit) and transcription factors. The application of different reagents yielded different patterns of positivity indicating that the validity of some common immunohistochemical reagents must be re-evaluated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1046-3976
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-6
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Plurihormonality in pituitary adenomas associated with acromegaly.
pubmed:affiliation
Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Canada. fateme.salehi@utoronto.ca
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't