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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-11-26
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pubmed:abstractText |
Oxidative stress, the imbalance between production and removal of reactive oxygen species (ROS), is implicated in the process of cardiovascular aging. Membrane-associated NAD(P)H oxidase system is the most important source of ROS in vascular cells. p22(phox), a critical component of the NAD(P)H oxidase, has a polymorphic site on exon 4, associated with variable enzyme activity. The goal of this study is to investigate the effect of the p22(phox) C242T polymorphism on cardiovascular aging.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1874-1754
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pubmed:author |
pubmed-author:ChoYoung-SeokYS,
pubmed-author:ChoiDong-JuDJ,
pubmed-author:ChoiYoon-HoYH,
pubmed-author:KangSeo YoungSY,
pubmed-author:KimCheol-HoCH,
pubmed-author:KimHyo-SooHS,
pubmed-author:KimKwang-IlKI,
pubmed-author:KwonIn SoonIS,
pubmed-author:NaJung-EunJE,
pubmed-author:OhByung-HeeBH,
pubmed-author:ParkSang-ChulSC
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18-22
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pubmed:meshHeading |
pubmed-meshheading:17307262-Adult,
pubmed-meshheading:17307262-Aged,
pubmed-meshheading:17307262-Aged, 80 and over,
pubmed-meshheading:17307262-Aging,
pubmed-meshheading:17307262-Blood Vessels,
pubmed-meshheading:17307262-DNA,
pubmed-meshheading:17307262-Female,
pubmed-meshheading:17307262-Gene Frequency,
pubmed-meshheading:17307262-Genotype,
pubmed-meshheading:17307262-Humans,
pubmed-meshheading:17307262-Korea,
pubmed-meshheading:17307262-Male,
pubmed-meshheading:17307262-Middle Aged,
pubmed-meshheading:17307262-NADPH Oxidase,
pubmed-meshheading:17307262-Oxidative Stress,
pubmed-meshheading:17307262-Polymerase Chain Reaction,
pubmed-meshheading:17307262-Polymorphism, Genetic
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pubmed:year |
2007
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pubmed:articleTitle |
Impact of NAD(P)H oxidase p22 phox gene polymorphism on vascular aging in Korean centenarian and nonagenarian.
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pubmed:affiliation |
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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