Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2007-4-9
pubmed:abstractText
Complex cognitive operations such as memory formation and decision-making are thought to be mediated not by single, isolated brain structures but by multiple, connected brain areas. To facilitate studies on the neural communication between connected brain structures, we developed a multi-electrode microdrive for chronically recording ensembles of neurons in two different brain areas simultaneously. The "split drive" contains 14 independently movable microdrivers that were designed to hold tetrodes and to permit day-to-day adjustment of dorsoventral position in the brain. The limited weight of the drive allowed rats to adjust well to the headstage after recovering from surgery and permitted stable recording sessions across at least several weeks. In addition to describing the design and assembly of the split drive, we also discuss some important individual parts of microdrives used for tetrode recordings in general. Furthermore, the split drive was applied to two widely separated and connected brain structures, the hippocampus and ventral striatum. From these two areas, stable ensemble recordings were conducted in rats performing a reward-searching task on a triangular track, yielding group sizes of about 15 and 25 units in the dorsal hippocampus and ventral striatum, respectively.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0165-0270
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
162
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-38
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
A split microdrive for simultaneous multi-electrode recordings from two brain areas in awake small animals.
pubmed:affiliation
Center for Neuroscience, Swammerdam Institute for Life Sciences, Faculty of Science, Universiteit van Amsterdam, P.O. Box 94084, Kruislaan 320, 1090 GB Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural