Linked Life Data

17306549

Source:http://linkedlifedata.com/resource/pubmed/id/17306549

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-3-13
pubmed:abstractText
The hemolytic activity of a collection of 63 steroid saponins was determined. The correlations between these structures and their hemolytic and cytotoxic activities are discussed. It has been demonstrated that the hemolytic activity of steroid saponins is highly dependent on their structures, that is, the sugar length, the sugar linkage, the substitutes on the sugar, as well as the aglycone. It has also been disclosed that the hemolytic activity and cytotoxicity of steroid saponins are not correlated. These results suggest that steroid saponins execute hemolysis and cytotoxic activity in different mechanisms, and encourage to develop steroid saponins into potent antitumor agents devoid of the detrimental effect of hemolysis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0968-0896
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2528-32
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins.
pubmed:affiliation
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't