Linked Life Data

17305506

Source:http://linkedlifedata.com/resource/pubmed/id/17305506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-2-19
pubmed:abstractText
Cytokines are involved in osteoarthritis (OA) at several levels. They are involved in primary cartilage damage, but also in synovial activation that is observed in osteoarthritic joints. From in vitro studies and animal models for OA, several cytokines have been identified that are potential targets for OA therapy. Two promising targets are the destructive cytokine Interleukin-1 (IL-1) and the anabolic growth factor transforming growth factor (TGF)beta and these will be discussed in more detail. Inhibition of IL-1 has been proven to result in amelioration of osteoarthritis-like pathology in animal models and the role of IL-1 is substantiated in studies in IL-1 deficient mice. In contrast, application of the anabolic growth factor TGFbeta may provide an alternative approach to promote cartilage integrity and repair. TGFbeta is a potent stimulator of chondrocyte matrix production, and therefore has a potency to repair already damaged cartilage. However, TGFbeta induces tissue fibrosis and osteophytes at the joint margins and can only be applied to promote cartilage repair when these side effects can be blocked. This appears possible with concomitant, compartmentalized application of selective inhibitors of TGFbeta in soft tissues, using local gene therapy with inhibitory Smad 6 and 7. Since OA is often limited to a few joints, local gene therapy may provide a suitable way to treat OA patients. Depending on the phenotype of a particular OA patient, e.g. with or without marked synovial activation, treatment may be focused mainly on suppression of catabolism or stimulation of anabolism, but combination therapy seems most warranted.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1873-5592
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-92
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Cytokine targeting in osteoarthritis.
pubmed:affiliation
Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. a.blom@reuma.umcn.nl
pubmed:publicationType
Journal Article, Review