Linked Life Data

17304823

Source:http://linkedlifedata.com/resource/pubmed/id/17304823

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-2-19
pubmed:abstractText
Schistosomes are intravascular platyhelminth parasites that are exposed in the blood stream to host immunological effectors. Antibody-dependent cell-mediated cytotoxicity (ADCC) can act in vitro to kill the parasites, and this has been proposed as one important mechanism of antiworm immunity in vivo. In this study, we examined sections of adult Schistosoma mansoni in situ, within the vasculature of strains of mice that exhibit low (Balb/c) or high (CBA) pathology, and in the vasculature of infected chimpanzees, for evidence of cellular inflammation around the worms. In both mouse strains, we observe robust cellular inflammation around the parasite eggs in the intestines and liver tissue. However, we detect no overt cellular inflammation around the mature parasites in vivo. Likewise in the vasculature of infected chimpanzees, no immune cell accumulations are detected around adult schistosomes in situ. These data suggest that the parasites can promote a polar immune response that targets eggs (and assists the eggs to exit the host and continue the life cycle) but that does not effectively target the source of those eggs, namely, the adult worms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-3395
pubmed:author
pubmed:issnType
Print
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1365-9
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
No overt cellular inflammation around intravascular schistosomes in vivo.
pubmed:affiliation
Department of Biomedical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, Massachusetts 01536, USA.
pubmed:publicationType
Journal Article