|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1992-2-18
|
|
pubmed:abstractText |
Plasmid-free strains of Yersinia pseudotuberculosis induce aggregation of human platelets in vitro. It appears that this phenomenon is mediated by invasin (Inv), a 103-kDa outer membrane protein that permits bacteria to penetrate mammalian cells, since (i) an isogenic inv-deficient mutant failed to aggregate platelets compared with the parental strain; (ii) a monoclonal antibody directed against invasin inhibited platelet aggregation; (iii) Inv+ Escherichia coli HB101 promoted platelet aggregation. Platelet receptors for invasin were identified by using a panel of anti-platelet glycoprotein monoclonal antibodies in a bacterial adhesion assay. We found that bacteria bind to platelet membrane glycoproteins Ic and IIa. Electron microscopic study of bacterium-platelet interactions also revealed that bacteria expressing invasin attach to and are phagocytized by thrombocytes, in contrast to inv-deficient bacteria, indicating that these anucleated cells are able to internalize bacteria in vitro after specific interaction with invasin.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-1688838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-1693333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-1705028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-1971256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2166336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2191183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2199285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2201305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2307522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2311122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-232214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2401564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2513330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2642465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2670888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2693898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2693899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2833444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2840402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2850443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2967289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2971621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-2995819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-3034735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-3043229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-3058389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-3112008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-3294185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-3304658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-3413117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-352956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-3547579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-4031037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-4108333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-4400052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-479376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-5002629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-5320283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-6188697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-627836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-6403459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-6749681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-6790437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-6798925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-7037646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1730468-7400626
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0019-9567
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
60
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
366-73
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:1730468-Adhesins, Bacterial,
pubmed-meshheading:1730468-Bacterial Adhesion,
pubmed-meshheading:1730468-Bacterial Proteins,
pubmed-meshheading:1730468-Humans,
pubmed-meshheading:1730468-Phagocytosis,
pubmed-meshheading:1730468-Platelet Aggregation,
pubmed-meshheading:1730468-Platelet Membrane Glycoproteins,
pubmed-meshheading:1730468-Receptors, Very Late Antigen,
pubmed-meshheading:1730468-Yersinia pseudotuberculosis
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Human platelet aggregation by Yersinia pseudotuberculosis is mediated by invasin.
|
|
pubmed:affiliation |
Laboratoire de Microbiologie, Faculté de Médecine Necker-Enfants Malades, Paris, France.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
