| pubmed-article:17304155 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17304155 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:17304155 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:17304155 | lifeskim:mentions | umls-concept:C0026933 | lld:lifeskim |
| pubmed-article:17304155 | lifeskim:mentions | umls-concept:C0085149 | lld:lifeskim |
| pubmed-article:17304155 | lifeskim:mentions | umls-concept:C0812407 | lld:lifeskim |
| pubmed-article:17304155 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:17304155 | lifeskim:mentions | umls-concept:C1707479 | lld:lifeskim |
| pubmed-article:17304155 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17304155 | pubmed:dateCreated | 2007-2-16 | lld:pubmed |
| pubmed-article:17304155 | pubmed:abstractText | Mycophenolate mofetil [MMF, the prodrug of mycophenolic acid (MPA)] is usually administered at double doses with cyclosporine than with tacrolimus because it is believed that MPA exposure is lower during cyclosporine therapy. This study aimed to compare 12 hour, steady-state concentration-time profiles of MPA and its phenol- and acyl-glucuronide metabolites (MPAG and AcMPAG, respectively) in stable kidney transplant recipients maintained either on cyclosporine (n = 12) or tacrolimus (n = 12). During the absorption phase in the cyclosporine group, dose-normalized concentrations of total and free MPA were significantly higher but the overall area under the concentration-time curve (AUC0-12) was not significantly different. Additionally, exposure to AcMPAG was higher in the cyclosporine group (P < 0.05). Ten of 12 patients in the cyclosporine group were on ketoconazole therapy; however, the exposure to MPA or MPAG was not different when MMF was given orally to Sprague-Dawley rats with or without ketoconazole. In conclusion, cyclosporine modulates the disposition of MPA and metabolites differently from tacrolimus; however, patients on cyclosporine may not require double doses of MMF to achieve the same exposure. | lld:pubmed |
| pubmed-article:17304155 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17304155 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17304155 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17304155 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17304155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17304155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17304155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17304155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17304155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17304155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17304155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17304155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17304155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17304155 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17304155 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:17304155 | pubmed:issn | 0163-4356 | lld:pubmed |
| pubmed-article:17304155 | pubmed:author | pubmed-author:AkhlaghiFatem... | lld:pubmed |
| pubmed-article:17304155 | pubmed:author | pubmed-author:GohhReginald... | lld:pubmed |
| pubmed-article:17304155 | pubmed:author | pubmed-author:PatelChirag... | lld:pubmed |
| pubmed-article:17304155 | pubmed:author | pubmed-author:HarmonMatthew... | lld:pubmed |
| pubmed-article:17304155 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17304155 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:17304155 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17304155 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17304155 | pubmed:pagination | 87-95 | lld:pubmed |
| pubmed-article:17304155 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
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| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
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| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:meshHeading | pubmed-meshheading:17304155... | lld:pubmed |
| pubmed-article:17304155 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17304155 | pubmed:articleTitle | Concentrations of mycophenolic acid and glucuronide metabolites under concomitant therapy with cyclosporine or tacrolimus. | lld:pubmed |
| pubmed-article:17304155 | pubmed:affiliation | Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA. | lld:pubmed |
| pubmed-article:17304155 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17304155 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:17304155 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17304155 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
