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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-2-16
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pubmed:abstractText |
Mycophenolate mofetil [MMF, the prodrug of mycophenolic acid (MPA)] is usually administered at double doses with cyclosporine than with tacrolimus because it is believed that MPA exposure is lower during cyclosporine therapy. This study aimed to compare 12 hour, steady-state concentration-time profiles of MPA and its phenol- and acyl-glucuronide metabolites (MPAG and AcMPAG, respectively) in stable kidney transplant recipients maintained either on cyclosporine (n = 12) or tacrolimus (n = 12). During the absorption phase in the cyclosporine group, dose-normalized concentrations of total and free MPA were significantly higher but the overall area under the concentration-time curve (AUC0-12) was not significantly different. Additionally, exposure to AcMPAG was higher in the cyclosporine group (P < 0.05). Ten of 12 patients in the cyclosporine group were on ketoconazole therapy; however, the exposure to MPA or MPAG was not different when MMF was given orally to Sprague-Dawley rats with or without ketoconazole. In conclusion, cyclosporine modulates the disposition of MPA and metabolites differently from tacrolimus; however, patients on cyclosporine may not require double doses of MMF to achieve the same exposure.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0163-4356
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-95
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17304155-Administration, Oral,
pubmed-meshheading:17304155-Aged,
pubmed-meshheading:17304155-Animals,
pubmed-meshheading:17304155-Antibiotics, Antineoplastic,
pubmed-meshheading:17304155-Area Under Curve,
pubmed-meshheading:17304155-Cyclosporine,
pubmed-meshheading:17304155-Diabetes Mellitus,
pubmed-meshheading:17304155-Dose-Response Relationship, Drug,
pubmed-meshheading:17304155-Drug Therapy, Combination,
pubmed-meshheading:17304155-Female,
pubmed-meshheading:17304155-Glucuronides,
pubmed-meshheading:17304155-Humans,
pubmed-meshheading:17304155-Immunosuppressive Agents,
pubmed-meshheading:17304155-Ketoconazole,
pubmed-meshheading:17304155-Kidney Transplantation,
pubmed-meshheading:17304155-Male,
pubmed-meshheading:17304155-Middle Aged,
pubmed-meshheading:17304155-Mycophenolic Acid,
pubmed-meshheading:17304155-Prednisone,
pubmed-meshheading:17304155-Rats,
pubmed-meshheading:17304155-Rats, Sprague-Dawley,
pubmed-meshheading:17304155-Tacrolimus
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pubmed:year |
2007
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pubmed:articleTitle |
Concentrations of mycophenolic acid and glucuronide metabolites under concomitant therapy with cyclosporine or tacrolimus.
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pubmed:affiliation |
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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