Linked Life Data

17303824

Source:http://linkedlifedata.com/resource/pubmed/id/17303824

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-4-16
pubmed:abstractText
Salivary diagnostics for oral as well as systemic diseases is dependent on the identification of biomolecules reflecting a characteristic change in presence, absence, composition, or structure of saliva components found under healthy conditions. Most of the biomarkers suitable for diagnostics comprise proteins and peptides. The usefulness of salivary proteins for diagnostics requires the recognition of typical features, which make saliva as a body fluid unique. Salivary secretions reflect a degree of redundancy displayed by extensive polymorphisms forming families for each of the major salivary proteins. The structural differences among these polymorphic isoforms range from distinct to subtle, which may in some cases not even affect the mass of different family members. To facilitate the use of modern state-of-the-art proteomics and the development of nanotechnology-based analytical approaches in the field of diagnostics, the salient features of the major salivary protein families are reviewed at the molecular level. Knowledge of the structure and function of salivary gland-derived proteins/peptides has a critical impact on the rapid and correct identification of biomarkers, whether they originate from exocrine or non-exocrine sources.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1098
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
22-50
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Salivary proteome and its genetic polymorphisms.
pubmed:affiliation
Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, Boston, Massachusetts 02118, USA. fropp@bu.edu
pubmed:publicationType
Journal Article, Comparative Study, Review, Research Support, N.I.H., Extramural