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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-4-2
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pubmed:abstractText |
The high-affinity choline transporter (CHT1) system is an attractive target for the development of positron emission tomography (PET) biomarkers to probe brain, cardiac, and cancer diseases. An efficient and convenient synthesis of new radiolabeled CHT1 inhibitors [(11)C]hemicholinium-3 and [(18)F]hemicholinium-3 by solid-phase extraction (SPE) technique using a cation-exchange CM Sep-Pak cartridge has been well developed. The preliminary evaluation of both tracers through biodistribution studies in 9L-glioma rats has been performed, and the uptakes in the heart and tumor were observed, while very low brain uptake was seen.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:DeGradoTimothy RTR,
pubmed-author:GaoMingzhangM,
pubmed-author:GrohWilliam JWJ,
pubmed-author:HaraToshihikoT,
pubmed-author:HutchinsGary DGD,
pubmed-author:LopshireJohn CJC,
pubmed-author:MillerMichael AMA,
pubmed-author:MockBruce HBH,
pubmed-author:NazihRachidR,
pubmed-author:ReceveurTim JTJ,
pubmed-author:WangShuyanS,
pubmed-author:ZhengQi-HuangQH,
pubmed-author:ZipesDouglas PDP
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2220-4
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17303422-Animals,
pubmed-meshheading:17303422-Brain,
pubmed-meshheading:17303422-Carbon Radioisotopes,
pubmed-meshheading:17303422-Cation Transport Proteins,
pubmed-meshheading:17303422-Fluorine Radioisotopes,
pubmed-meshheading:17303422-Glioma,
pubmed-meshheading:17303422-Hemicholinium 3,
pubmed-meshheading:17303422-Myocardium,
pubmed-meshheading:17303422-Positron-Emission Tomography,
pubmed-meshheading:17303422-Protein Binding,
pubmed-meshheading:17303422-Radiopharmaceuticals,
pubmed-meshheading:17303422-Rats
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis and biodistribution of new radiolabeled high-affinity choline transporter inhibitors [11C]hemicholinium-3 and [18F]hemicholinium-3.
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pubmed:affiliation |
Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. qzheng@iupui.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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