| pubmed-article:17303116 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17303116 | lifeskim:mentions | umls-concept:C0028040 | lld:lifeskim |
| pubmed-article:17303116 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:17303116 | lifeskim:mentions | umls-concept:C0082341 | lld:lifeskim |
| pubmed-article:17303116 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17303116 | lifeskim:mentions | umls-concept:C0444706 | lld:lifeskim |
| pubmed-article:17303116 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:17303116 | lifeskim:mentions | umls-concept:C0086960 | lld:lifeskim |
| pubmed-article:17303116 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:17303116 | pubmed:dateCreated | 2007-3-2 | lld:pubmed |
| pubmed-article:17303116 | pubmed:abstractText | The dopamine D3 receptor is primarily localized within the mesocorticolimbic system, and may therefore have potential as a pharmacotherapeutic target for the treatment of drug dependence. Studies have shown that the selective dopamine D3 receptor antagonist SB-277011A reduces a variety of dependence-related behavioral effects of cocaine, alcohol and heroin. A previous study examining SB-277011A on nicotine self-administration using relatively low doses of the antagonist and a low response requirement for nicotine found no effect on drug-taking behavior per se, whereas reinstatement of nicotine-seeking was reduced. The purpose of the present study was to further examine the effects of higher doses of SB-277011A on nicotine self-administration in rats under a progressive-ratio (PR) schedule, which imposes relatively high response requirements for nicotine. Rats were trained to respond under a PR schedule of either nicotine or food reinforcement. Once responding was stable, SB-277011A (3-56 mg/kg) or vehicle was administered i.p. 1 h prior to the operant session. The highest dose tested significantly decreased the mean number of reinforcers and mean response rates in the nicotine self-administration group, but had no effect on either the mean number of reinforcers or response rate in the food group. In a separate set of experiments, the effects of SB-277011A on locomotor activity were measured. At the dose that significantly decreased nicotine self-administration, total distance traveled was also significantly decreased, suggesting that the effect on operant responding at the high dose of SB-277011A is at a threshold for motor effects and may not be directly mediated by an action at dopamine D3 receptors. | lld:pubmed |
| pubmed-article:17303116 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17303116 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17303116 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17303116 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17303116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17303116 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17303116 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:17303116 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:17303116 | pubmed:author | pubmed-author:CorrigallWill... | lld:pubmed |
| pubmed-article:17303116 | pubmed:author | pubmed-author:LeSageMark... | lld:pubmed |
| pubmed-article:17303116 | pubmed:author | pubmed-author:HeidbrederChr... | lld:pubmed |
| pubmed-article:17303116 | pubmed:author | pubmed-author:RossJason TJT | lld:pubmed |
| pubmed-article:17303116 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17303116 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:17303116 | pubmed:volume | 559 | lld:pubmed |
| pubmed-article:17303116 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17303116 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17303116 | pubmed:pagination | 173-9 | lld:pubmed |
| pubmed-article:17303116 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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| pubmed-article:17303116 | pubmed:meshHeading | pubmed-meshheading:17303116... | lld:pubmed |
| pubmed-article:17303116 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17303116 | pubmed:articleTitle | Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as measured by a progressive-ratio schedule in rats. | lld:pubmed |
| pubmed-article:17303116 | pubmed:affiliation | Minneapolis Medical Research Foundation, 914 South 8th Street, Minneapolis, MN 55404, USA. | lld:pubmed |
| pubmed-article:17303116 | pubmed:publicationType | Journal Article | lld:pubmed |
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